ArticleNature communications2016
Programming a topologically constrained DNA nanostructure into a sensor.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- TopCas: Topology-Gated Cas12a via DNA-RNA Chimeric Circular crRNA for Amplification-Free Nucleic Acid Detection and Conditional Gene Editing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolution.EBioMedicine · 2025Article
- In situ imaging of intracellular miRNAs in tumour cells by branched hybridisation chain reaction.Cell proliferation · 2024Article
- DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration.Nature communications · 2023Article
- Biomolecular sensors for advanced physiological monitoring.Nature reviews bioengineering · 2023Review
- Engineering a Ligase Binding DNA Aptamer into a Templating DNA Scaffold to Guide the Selective Synthesis of Circular DNAzymes and DNA Aptamers.Journal of the American Chemical Society · 2023Article
- A multiplexed circulating tumor DNA detection platform engineered from 3D-coded interlocked DNA rings.Bioactive materials · 2022Article
- RNA-cleaving DNAzymes as a diagnostic and therapeutic agent against antimicrobial resistant bacteria.Current genetics · 2022Review
- Rolling Circle Amplification as an Efficient Analytical Tool for Rapid Detection of Contaminants in Aqueous Environments.Biosensors · 2021Review
- Biosensing with DNAzymes.Chemical Society reviews · 2021Review
- DNA Nanostructures in the Fight Against Infectious Diseases.Advanced nanobiomed research · 2021Article
- Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.Sensors (Basel, Switzerland) · 2020Review
- Evolution of a highly functional circular DNA aptamer in serum.Nucleic acids research · 2020Article
- Facile Characterization of Topology of DNA Catenanes.Biophysical journal · 2020Article
- AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.Journal of the American Chemical Society · 2020Article
- Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids.Nature communications · 2020Article
- Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology.iScience · 2020Review
- A Simple DNAzyme-Based Fluorescent Assay for Klebsiella pneumoniae.Chembiochem : a European journal of chemical biology · 2019Article
- Terminal hairpin in oligonucleotide dominantly prioritizes intramolecular cyclization by T4 ligase over intermolecular polymerization: an exclusive methodology for producing ssDNA rings.Nucleic acids research · 2018Article
- Cyclization of secondarily structured oligonucleotides to single-stranded rings by usingRSC advances · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many rationally engineered DNA nanostructures use mechanically interlocked topologies to connect individual DNA components, and their physical connectivity is achieved through the formation of a strong linking duplex. The existence of such a structural element also poses a significant topological constraint on functions of component rings. Herein, we hypothesize and confirm that DNA catenanes with a strong linking duplex prevent component rings from acting as the template for rolling circle amplification (RCA). However, by using an RNA-containing DNA [2] catenane with a strong linking duplex, we show that a stimuli-responsive RNA-cleaving DNAzyme can linearize one component ring, and thus enable RCA, producing an ultra-sensitive biosensing system. As an example, a DNA catenane biosensor is engineered to detect the model bacterial pathogen Escherichia coli through binding of a secreted protein, with a detection limit of 10 cells ml(-1), thus establishing a new platform for further applications of mechanically interlocked DNA nanostructures.
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