Evidence map›Paper›PMID 27337641›Full record

ArticleOrganic letters2016

Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions.

Adam B Weinstein, Jonathan A Ellman

Abstract read
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam B WeinsteinDepartment of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Jonathan A EllmanDepartment of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
C-H Functionalization for the Synthesis of Amines and Nitrogen HeterocyclesR01GM069559 · NIGMS · YALE UNIVERSITY · PI ELLMAN, JONATHAN A · 2004 to 2017
$5.4M
Cobalt Catalyzed Vinylic C H Additions Into IminesF32GM112454 · NIGMS · YALE UNIVERSITY · PI WEINSTEIN, ADAM BENJAMIN · 2014 to 2016
$124k
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS F32 GM112454NIGMS NIH HHS R01 GM069559
6 · The paper itself

Abstract

The development of Rh(III)-catalyzed C-H conjugate addition/cyclization reactions that provide access to synthetically useful fused bi- and tricyclic nitrogen heterocycles is reported. A broad scope of C-H functionalization substrates and electrophilic olefin coupling partners is effective, and depending on the nature of the directing group, cyclic imide, amide, or heteroaromatic products are obtained. An efficient synthesis of a pyrrolophenanthridine alkaloid natural product, oxoassoanine, highlights the utility of this method.

Indexed as

AlkenesAmidesCatalysisCyclizationHeterocyclic CompoundsImidesMolecular StructureRhodiumAlkenesAmidesHeterocyclic CompoundsImidesRhodium

Identifiers

PMID27337641
PMCPMC4973575

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.