Observational studyThe Journal of clinical psychiatry2016
Nocturnal Wakefulness Is Associated With Next-Day Suicidal Ideation in Major Depressive Disorder and Bipolar Disorder.
Observational study in The Journal of clinical psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
Long-term Observation of Participants With Mood Disorders
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Sleep disturbances as risk factors for suicidal thoughts and behaviours: a meta-analysis of longitudinal studies.Scientific reports · 2020Pooled it
- Objective measurement of sleep, heart rate, heart rate variability, and physical activity in suicidality: A systematic review.Journal of affective disorders · 2020Pooled it
- Examining the role of psychological factors in the relationship between sleep problems and suicide.Clinical psychology review · 2017Pooled it
- Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression.Translational psychiatry · 2024Trial
- Antisuicidal Response Following Ketamine Infusion Is Associated With Decreased Nighttime Wakefulness in Major Depressive Disorder and Bipolar Disorder.The Journal of clinical psychiatryTrial
- Reduced Slow-Wave Sleep and Sleep-Disordered Breathing Are Linked to Suicidal Ideation in Major Depressive Disorder.Brain and behavior · 2026Article
- Sleep Disturbances, Psychosis Symptoms, and Suicidal Ideation in First Episode Psychosis: An Exploratory Mixed-Methods Study.Schizophrenia bulletin open · 2026Article
- Understanding Latine disparities in nocturnal wakefulness as a suicide risk factor.Sleep epidemiology · 2025Article
- Older injured adults reported sleep disturbances: a cross-sectional study.Journal of patient-reported outcomes · 2025Article
- Integrating Behavioral Health Into Monitoring and Surveillance During Public Health Emergencies: Challenges and Opportunities.Disaster medicine and public health preparedness · 2024Review
- Sleep Disturbance and Subsequent Suicidal Behaviors in Preadolescence.JAMA network open · 2024Article
- Risk for Suicide and Homicide Peaks at Night: Findings From the National Violent Death Reporting System, 35 States, 2003-2017.The Journal of clinical psychiatry · 2024Article
- Examining sleep disturbance components as near-term predictors of suicide ideation in daily life.Psychiatry research · 2023Article
- Sleep disorders among patients suffering from road traffic injuries in an urban setting of Vietnam: an exploratory study.Scientific reports · 2023Article
- Effect of Ketamine on Sleep in Treatment-Resistant Depression: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Poor self-reported sleep quality associated with suicide risk in a community sample of American Indian adults.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Artificial intelligence assisted tools for the detection of anxiety and depression leading to suicidal ideation in adolescents: a review.Cognitive neurodynamics · 2022Review
- Sleep disturbance and suicide risk among sexual and gender minority people.Neurobiology of stress · 2022Article
- The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.Frontiers in network physiology · 2022Article
- The Dynamic Relationship Between Alpha and Beta Power and Next-Day Suicidal Ideation in Individuals With Treatment-Resistant Depression.Biological psychiatry global open science · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSelf-reported sleep disturbances may confer elevated risk for suicidal ideation, suicide attempts, and death. However, limited research has evaluated polysomnographically determined sleep disturbance as an acute physiologic risk factor for suicidal thoughts. This study sought to investigate the relationship between nocturnal wakefulness in association with next-day suicidal ideation using overnight polysomnography assessment from data collected between 2006 and 2013.
methodsSixty-five participants with DSM-IV-diagnosed major depressive disorder or bipolar depression underwent overnight polysomnography monitoring in a sleep laboratory. The Hamilton Depression Rating Scale (HDRS) was administered the morning after polysomnography recording to assess next-day suicidal ideation, severity of depressive symptoms, and subjective sleep disturbances.
resultsUsing a generalized linear mixed model, a significant time-by-ideation interaction was found indicating greater nocturnal wakefulness at 4:00 am among participants with suicidal ideation (F4,136 = 3.65, P = .007). Increased time awake during the 4:00 am hour (4:00 to 4:59) was significantly associated with elevated suicidal thoughts the next day (standardized β = 0.31, P = .008). This relationship persisted after controlling for age, gender, diagnosis, and severity of depressive symptoms.
conclusionsGreater nocturnal wakefulness, particularly in the early morning hours, was significantly associated with next-day suicidal thoughts. Polysomnographically documented sleep disruption at specific times of night may represent an acute risk factor of suicidal ideation that warrants additional research.
trial registrationClinicalTrials.gov identifier: NCT00024635.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.