ArticlePloS one2016
BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Dietary Spirulina (Animals : an open access journal from MDPI · 2025Article
- Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish.iScience · 2024Article
- Transcription Pattern of Neurotrophic Factors and Their Receptors in Adult Zebrafish Spinal Cord.International journal of molecular sciences · 2023Article
- Effects of Two Environmental Enrichment Methods on Cognitive Ability and Growth Performance of Juvenile Black RockfishAnimals : an open access journal from MDPI · 2023Article
- BDNF and its signaling in cancer.Journal of cancer research and clinical oncology · 2023Review
- Evaluation of the Antiseizure Activity of Endemic PlantInternational journal of molecular sciences · 2023Article
- Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson's disease model.Frontiers in pharmacology · 2023Article
- Temperature- and chemical-induced neurotoxicity in zebrafish.Frontiers in physiology · 2023Review
- Individual differences and knockout in zebrafish reveal similar cognitive effects of BDNF between teleosts and mammals.Proceedings. Biological sciences · 2022Article
- Article
- Neurotrophins in Zebrafish Taste Buds.Animals : an open access journal from MDPI · 2022Article
- Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney.Veterinary sciences · 2022Article
- Localization of BDNF and Calretinin in Olfactory Epithelium and Taste Buds of Zebrafish (International journal of molecular sciences · 2022Article
- Loss of circadian rhythmicity iniScience · 2022Article
- Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (International journal of molecular sciences · 2021Article
- Neurotrophins Time Point Intervention after Traumatic Brain Injury: From Zebrafish to Human.International journal of molecular sciences · 2021Review
- Neurotrophins in the Brain of Teleost Fish: The State of the Art.Advances in experimental medicine and biology · 2021Review
- Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish.Molecular neurobiology · 2020Article
- Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.International journal of molecular sciences · 2020Article
- Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has emerged as an active mediator in many essential functions in the central nervous system of mammals. BDNF plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. Despite the vast literature present in mammals, studies devoted to BDNF in the brain of other animal models are scarse. Zebrafish is a teleost fish widely known for developmental genetic studies and is emerging as model for translational neuroscience research. In addition, its brain shows many sites of adult neurogenesis allowing higher regenerative properties after traumatic injuries. To add further knowledge on neurotrophic factors in vertebrate brain models, we decided to determine the distribution of bdnf mRNAs in the larval and adult zebrafish brain and to characterize the phenotype of cells expressing bdnf mRNAs by means of double staining studies. Our results showed that bdnf mRNAs were widely expressed in the brain of 7 days old larvae and throughout the whole brain of mature female and male zebrafish. In adults, bdnf mRNAs were mainly observed in the dorsal telencephalon, preoptic area, dorsal thalamus, posterior tuberculum, hypothalamus, synencephalon, optic tectum and medulla oblongata. By combining immunohistochemistry with in situ hybridization, we showed that bdnf mRNAs were never expressed by radial glial cells or proliferating cells. By contrast, bdnf transcripts were expressed in cells with neuronal phenotype in all brain regions investigated. Our results provide the first demonstration that the brain of zebrafish expresses bdnf mRNAs in neurons and open new fields of research on the role of the BDNF factor in brain mechanisms in normal and brain repairs situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.