ArticleMedicine2016
OPG and RANKL polymorphisms are associated with alcohol-induced osteonecrosis of the femoral head in the north area of China population in men.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Osteonecrosis of the femoral head: genetic basis.International orthopaedics · 2019Pooled it
- Addressing osteoblast senescence: Molecular pathways and the frontier of anti-ageing treatments.Clinical and translational medicine · 2025Review
- Impact of the Habit of Alcohol Consumption on the Success of the Implants: A Retrospective Study.Journal of pharmacy & bioallied sciences · 2024Article
- Association of Specific Genetic Polymorphisms with Atraumatic Osteonecrosis of the Femoral Head: A Narrative Review.Indian journal of orthopaedics · 2022Review
- Article
- Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Osteoblast function in patients with idiopathic osteonecrosis of the femoral head : implications for a possible novel therapy.Bone & joint research · 2021Article
- OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men.Journal of orthopaedic surgery and research · 2021Article
- Article
- Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease.Scientific reports · 2020Article
- Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population.BMC musculoskeletal disorders · 2020Article
- Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- IL-4 gene polymorphisms and their relation to steroid-induced osteonecrosis of the femoral head in Chinese population.Molecular genetics & genomic medicine · 2019Article
- Article
- Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse.International journal of biological sciences · 2018Article
- Article
- MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population.Oncotarget · 2017Article
- Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol-induced osteonecrosis of the femoral head (ONFH) is an important pathogenesis of nontraumatic ONFH. However, the mechanisms of the pathogenesis are still unknown. Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL) have been implicated in multiple functions including blocking osteoclast maturation, controlling vascular calcifications, and promoting tumor growth and metastasis. The purpose of this article was to explore the association between OPG and RANKL gene variants and alcohol-induced ONFH. Six hundred seventy male subjects (335 patients and 335 normal individuals) were enrolled in our study. We selected 24 single-nucleotide polymorphisms (SNPs) to evaluate the association between genetic susceptibility variants and alcohol-induced ONFH using the chi-square test and gene model analysis. Overall, the OPG SNPs (rs1032128 and rs11573828) were associated with the strongest increased risk of alcohol-induced ONFH in the recessive model (rs1032128: odds ratio [OR] 1.49, 95% confidence interval [CI] 1.00-2.22, P = 0.04 for G/A; rs11573828: OR 3.32, 95% CI 1.07-10.30, P = 0.03 for T/C). The RANKL SNP rs2200287 was also an increased risk factor (OR 3.65, 95% CI 1.53-8.47, P = 0.003 for T/C) in the recessive model. The rs11573856, rs3134056, and rs1564861 SNPs were considered protective factors for alcohol-induced ONFH. We concluded that OPG and RANKL polymorphisms were associated with the occurrence of alcohol-induced ONFH.
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Registered trials
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