SynthesisBritish journal of cancer2016
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 6 pooled it
7.5field-weighted citation impact, top 3% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Early-life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis of prospective studies.International journal of cancer · 2025Pooled it
- Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.European journal of epidemiology · 2024Pooled it
- Meta-Analysis of the Association between Dietary Inflammatory Index (DII) and Colorectal Cancer.Nutrients · 2022Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics.Nutrients · 2021Pooled it
- Body mass index and colorectal cancer risk: A Mendelian randomization study.Cancer science · 2021Pooled it
- Body Mass Index-Dependent Effect of Glucagon-Like Peptide 1 Receptor Agonist Therapy on Bowel Preparation Quality.Clinical and translational gastroenterology · 2026Article
- Article
- Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.International journal of cancer · 2026Article
- Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis.International journal of epidemiology · 2025Article
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Metabolic Dysregulation and Cancer Risk Program (MeDOC): a transdisciplinary approach to obesity-associated cancers.Journal of the National Cancer Institute · 2024Article
- Mendelian randomisation analysis for intestinal disease: achievement and future.eGastroenterology · 2024Review
- Article
- Editorial: Genetic obesity.Frontiers in endocrinology · 2023Article
- Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics.Obesity (Silver Spring, Md.) · 2022Article
- Multidisciplinary Progress in Obesity Research.Genes · 2022Review
- The timing of adiposity and changes in the life course on the risk of cancer.Cancer metastasis reviews · 2022Review
- Genetic Obesity Variants and Risk of Conventional Adenomas and Serrated Polyps.Digestive diseases and sciences · 2022Article
Corrections and comments
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Authors and funding
57 authors at 20 institutions in 7 countries.
David JarvisDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Jonathan S MitchellDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Kimmo PalinGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Sari TuupanenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Alexandra GylfeGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Ulrika A HänninenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Tatiana CajusoGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Tomas TanskanenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Johanna KondelinGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Eevi KaasinenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Antti-Pekka SarinInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Johan G ErikssonNational Institute for Health and Welfare, Helsinki 00271, Finland.
Harri RissanenNational Institute for Health and Welfare, Helsinki 00271, Finland.
Paul KnektNational Institute for Health and Welfare, Helsinki 00271, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki 00130, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki 00271, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki 00271, Finland.
Samuli RipattiInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
Heikki JärvinenDepartment of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki 00029, Finland.
Laura Renkonen-SinisaloDepartment of Surgery, Abdominal Center, Helsinki University Hospital Helsinki 00029, Finland.
Anna LepistöDepartment of Surgery, Abdominal Center, Helsinki University Hospital Helsinki 00029, Finland.
Jan BöhmDepartment of Pathology, Central Finland Central Hospital, Jyväskylä 40620, Finland.
Jukka-Pekka MeklinDepartment of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä 40620, Finland.
Nada A Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Claire PallesWellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Lynn MartinWellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Ella BarclayWellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Susan M FarringtonColon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Maria N TimofeevaColon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Brian F MeyerDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Salma M WakilDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 12713, Saudi Arabia.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK.
Christopher G SmithInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Shelley IdziaszczykInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Timothy S MaughanCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Richard KaplanMRC Clinical Trials Unit, Aviation House, London WC2B 6NH, UK.
Rachel KerrDepartment of Oncology, Oxford Cancer Centre, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
David KerrNuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Daniel D BuchananDepartment of Pathology, Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, VIC 3010, Australia.
Aung K WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC 3010, Australia.
John L HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC 3010, Australia.
Mark A JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC 3010, Australia.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Steve GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
David ContiDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Fred SchumacherDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Graham CaseyDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jussi TaipaleGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Lauri A AaltonenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki 00014, Helsinki, Finland.
Jeremy P CheadleInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Malcolm G DunlopColon Cancer Genetics Group, MRC Human Genetics Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Ian P TomlinsonWellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, Oxford OX3 7BN, UK.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
University of Helsinki · FIFinnish Institute for Health and Welfare · FICentre for Human Genetics · GBInstitute of Cancer Research · GBUniversity of Melbourne · AUCardiff University · GBKing Faisal Specialist Hospital & Research Centre · SAUniversity of Southern California · USWestern General Hospital · GBHelsinki University Hospital · FIBroad Institute · USCentral Finland Health Care District · FIChurchill Hospital · GBCRUK/MRC Oxford Institute for Radiation Oncology · GBFinland University · FIFolkhälsans Forskningscentrum · FIFred Hutch Cancer Center · USHospital District of Helsinki and Uusimaa · FIKarolinska Institutet · SELunenfeld-Tanenbaum Research Institute · CA
Funding
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5MUSC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MColon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3MFAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1MInherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4MThe Colon Cancer Family Registry: USC ConsortiumU24CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 2008 to 2011
$7.6MGenomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MAUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9MThe Colon Cancer Family Registry: AustralasiaU24CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2008 to 2011
$6.2MCancer Research UK 12076Cancer Research UK 15116Cancer Research UK 18927Cancer Research UK 20240CCR NIH HHS HHSN261201300011CMedical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MC_UU_12023/20Medical Research Council MR/K018647/1NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000121CNCI NIH HHS HHSN261201300012INCI NIH HHS HHSN261201300021CNCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035142NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502Wellcome Trust
Abstract
backgroundObservational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC.
methodsWe used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls.
resultsIn the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02-1.49, P=0.033), 1.59 (95% CI: 1.08-2.34, P=0.019) and 1.07 (95% CI: 1.03-1.13, P=0.018), respectively. There was no evidence for association between birth weight and CRC (OR=1.22, 95% CI: 0.89-1.67, P=0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10-1.44, P=7.7 × 10(-4)) and 1.40 (95% CI: 1.14-1.72, P=1.2 × 10(-3)), respectively.
conclusionsThese data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity.
Indexed as
AdiposityAdultColorectal NeoplasmsFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRandom Allocation
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