ArticleBritish journal of cancer2016
Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Prevention strategies for hereditary gynaecological cancer in Lynch syndrome.Familial cancer · 2026Review
- Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.International journal of cancer · 2025Article
- Changes in the malignant female reproductive system tumors disease spectrum at the Beijing obstetrics and gynecology hospital in the past 60 years.Frontiers in medicine · 2025Article
- Article
- Effects of RFRP‑3 on an ovariectomized estrogen‑primed rat model and HEC‑1A human endometrial carcinoma cells.Experimental and therapeutic medicine · 2023Article
- Magnetic resonance-based radiomics nomogram for predicting microsatellite instability status in endometrial cancer.Quantitative imaging in medicine and surgery · 2023Article
- Conservative Surgery in Endometrial Cancer.Journal of clinical medicine · 2021Review
- Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women with lynch syndrome.Hereditary cancer in clinical practice · 2021Article
- Fertility preserving management of early endometrial cancer in a patient cohort at the department of women's health at the university of Tuebingen.Archives of gynecology and obstetrics · 2021Article
- Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study.Familial cancer · 2020Article
- Endometrioid endometrial cancer "recurring" as high-grade serous adenocarcinoma in the inguinal lymph nodes in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?Hereditary cancer in clinical practice · 2019Article
- The practice of universal screening for Lynch syndrome in newly diagnosed endometrial carcinoma.Health science reports · 2018Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients.
methodsThe study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model was used to estimate the associations between lifestyle, hormonal, reproductive and medical factors and the risk of EC.
resultsIncreased EC risk was associated with type II diabetes and hypercholesterolaemia in univariable (HR 3.21, (95% CI 1.34-7.78), P=0.009 and HR 2.08, (95% CI 1.11-3.90), P=0.02; respectively) and with diabetes and duration of hormone replacement therapy (HRT) in multivariable analysis (HR 4.18 (95% CI 1.52-11.52), P=0.006 and HR 1.07 (95% CI 1.02-1.13), P=0.010; respectively).
conclusionsPrevention of diabetes and avoiding long-duration HRT are potential targets for reduction of EC risk in women with LS.
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