Evidence map›Paper›PMID 27336357›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Quantifying the Balance Between Total Bone Formation and Total Bone Resorption: An Index of Net Bone Formation.

Albert Shieh, Weijuan Han, Shinya Ishii, Gail A Greendale, Carolyn J Crandall, Arun S Karlamangla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. A bone resorption marker as predictor of rate of change in femoral neck size and strength during the menopause transition.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  17. Anti-Osteoporotic Effects of Kukoamine B Isolated fromInternational journal of molecular sciences · 2019
    Article
  18. Article
  19. Bone Health During the Menopause Transition and Beyond.Obstetrics and gynecology clinics of North America · 2018
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Albert ShiehDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Weijuan HanDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Shinya IshiiDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Gail A GreendaleDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Carolyn J CrandallDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Arun S KarlamanglaDivision of Endocrinology (A.S.), Department of Medicine, Division of Geriatrics (W.H., G.A.G., A.S.K.), Department of Medicine, and Division of General Internal Medicine and Health Services Research (C.J.C.), Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095-7073; and Department of Geriatric Medicine (S.I.), Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
SWAN Repository IVU01AG017719 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2000 to 2020
$25.0M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
NCATS NIH HHS UL1 TR000124NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG033067NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U01 AG017719NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

contextBone gain vs loss across the skeleton loss depends on the balance between total bone formation and total bone resorption.

objectiveThe objective of the study was to determine whether resorption and formation markers can be combined to gauge net bone formation across the skeleton.

designThe study included a cohort followed up across menopause transition (Study of Women's Health Across the Nation). SETTING AND

participantsCommunity-dwelling women, 42-52 years old, premenopausal or early perimenopausal at baseline, participated in the study. OUTCOME: The study included the following measures: 1) bone balance index (BBI) created by estimating the relationship between resorption (urinary N-telopeptide) and formation (osteocalcin) markers when the total formation equals the total resorption in 685 women with stable bone mineral density (BMD) (>5 y before the final menstrual period [FMP]) and applying this relationship to measured bone turnover markers in 216 women beginning to lose bone (≤2 y from FMP); and 2) annualized percentage declines over the following 3-4 years in the lumbar spine (LS) and femoral neck (FN) BMD.

resultsAdjusted for covariates, the BBI was greater (more favorable) in women with a greater body mass index (P = .03) and lower (less favorable) in women closer to the FMP (P = .007). Each SD decrement in BBI was associated with 0.27%/y faster LS BMD decline (P 0.04) and a 38% higher odds of faster-than-average loss of LS bone mass (P = .008, c-statistic 0.76). BBI was not associated with decline in FN BMD. Urinary N-telopeptide alone was not associated with either LS or FN BMD decline.

conclusionsAn index that quantifies net bone formation vs resorption can be created from bone turnover markers and may help identify individuals at high risk for LS bone loss.

Indexed as

Bone DensityHealth Status IndicatorsAdultBiomarkersBone RemodelingBone ResorptionCollagen Type IFemaleFollow-Up StudiesHomeostasisHumansLongitudinal StudiesMenopauseMiddle AgedOsteocalcinOsteogenesisBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideOsteocalcinPeptides

Identifiers

PMID27336357
PMCPMC4929845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.