ArticlePloS one2016
Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Ethylene glycol metabolism in the oleaginous yeast Rhodotorula toruloides.Applied microbiology and biotechnology · 2025Article
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- Metabolomics distinguishes different grades ofHeliyon · 2024Article
- Design, Analysis, and Implementation of a Novel Biochemical Pathway for Ethylene Glycol Production inACS synthetic biology · 2022Article
- Transcription Analysis of RecombinantJournal of microbiology and biotechnology · 2020Article
- Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives.Biotechnology for biofuels · 2020Review
- Systematic improvement of isobutanol production from D-xylose in engineered Saccharomyces cerevisiae.AMB Express · 2019Article
- Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives.Applied microbiology and biotechnology · 2019Review
- Online monitored characterization of Phocaeicola vulgatus for organic acid production using anaerobic microtiter plate cultivations.Biotechnology progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The efficient use of hemicellulose in the plant cell wall is critical for the economic conversion of plant biomass to renewable fuels and chemicals. Previously, the yeast Saccharomyces cerevisiae has been engineered to convert the hemicellulose-derived pentose sugars xylose and arabinose to d-xylulose-5-phosphate for conversion via the pentose phosphate pathway (PPP). However, efficient pentose utilization requires PPP optimization and may interfere with its roles in NADPH and pentose production. Here, we developed an alternative xylose utilization pathway that largely bypasses the PPP. In the new pathway, d-xylulose is converted to d-xylulose-1-phosphate, a novel metabolite to S. cerevisiae, which is then cleaved to glycolaldehyde and dihydroxyacetone phosphate. This synthetic pathway served as a platform for the biosynthesis of ethanol and ethylene glycol. The use of d-xylulose-1-phosphate as an entry point for xylose metabolism opens the way for optimizing chemical conversion of pentose sugars in S. cerevisiae in a modular fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.