ArticlePloS one2016
Subregional Shape Alterations in the Amygdala in Patients with Panic Disorder.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.Alpha psychiatry · 2025Pooled it
- A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice.Nature neuroscience · 2024Article
- Amygdala-driven apnea and the chemoreceptive origin of anxiety.Biological psychology · 2022Review
- Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety.Brain imaging and behavior · 2020Article
- A 3D Fully Convolutional Neural Network With Top-Down Attention-Guided Refinement for Accurate and Robust Automatic Segmentation of Amygdala and Its Subnuclei.Frontiers in neuroscience · 2020Article
- Smaller volumes in the lateral and basal nuclei of the amygdala in patients with panic disorder.PloS one · 2018Article
- Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects: Between Compensation and Resilience?Frontiers in psychiatry · 2018Article
- The Neurobiology of Panic: A Chronic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe amygdala has been known to play a pivotal role in mediating fear-related responses including panic attacks. Given the functionally distinct role of the amygdalar subregions, morphometric measurements of the amygdala may point to the pathophysiological mechanisms underlying panic disorder. The current study aimed to determine the global and local morphometric alterations of the amygdala related to panic disorder.
methodsVolumetric and surface-based morphometric approach to high-resolution three-dimensional T1-weighted images was used to examine the structural variations of the amygdala, with respect to extent and location, in 23 patients with panic disorder and 31 matched healthy individuals.
resultsThere were no significant differences in bilateral amygdalar volumes between patients with panic disorder and healthy individuals despite a trend-level right amygdalar volume reduction related to panic disorder (right, β = -0.23, p = 0.09, Cohen's d = 0.51; left, β = -0.18, p = 0.19, Cohen's d = 0.45). Amygdalar subregions were localized into three groups including the superficial, centromedial, and laterobasal groups based on the cytoarchitectonically defined probability map. Surface-based morphometric analysis revealed shape alterations in the laterobasal and centromedial groups of the right amygdala in patients with panic disorder (false discovery rate corrected p < 0.05).
conclusionsThe current findings suggest that subregion-specific shape alterations in the right amygdala may be involved in the development and maintenance of panic disorder, which may be attributed to the cause or effects of amygdalar hyperactivation.
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