Evidence map›Paper›PMID 27336235›Full record

ArticleEnvironmental research2016

Associations of oxidative stress and inflammatory biomarkers with chemically-characterized air pollutant exposures in an elderly cohort.

Xian Zhang, Norbert Staimer, Daniel L Gillen, Tomas Tjoa, James J Schauer, Martin M Shafer, Sina Hasheminassab, Payam Pakbin, Nosratola D Vaziri, Constantinos Sioutas and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 7 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
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  7. Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies.International journal of environmental research and public health · 2018
    Pooled it
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  19. Air Quality and Cancer Prevalence Trends across the Sub-Saharan African Regions during 2005-2020.International journal of environmental research and public health · 2022
    Article
  20. Tissue-Protective Effect of Erdosteine on Multiple-Organ Injuries Induced by Fine Particulate Matter.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xian ZhangDepartment of Epidemiology, School of Medicine, University of California, Irvine, CA, USA.
Norbert StaimerDepartment of Epidemiology, School of Medicine, University of California, Irvine, CA, USA.
Daniel L GillenDepartment of Statistics, School of Information and Computer Sciences, University of California, Irvine, CA, USA.
Tomas TjoaDepartment of Epidemiology, School of Medicine, University of California, Irvine, CA, USA.
James J SchauerUniversity of Wisconsin-Madison, Environmental Chemistry and Technology Program, Madison, WI, USA.
Martin M ShaferUniversity of Wisconsin-Madison, Environmental Chemistry and Technology Program, Madison, WI, USA.
Sina HasheminassabDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Payam PakbinDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Nosratola D VaziriDivision of Nephrology and Hypertension, Department of Medicine, School of Medicine, University of California, Irvine, CA, USA.
Constantinos SioutasDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Ralph J DelfinoDepartment of Epidemiology, School of Medicine, University of California, Irvine, CA, USA. Electronic address: rdelfino@uci.edu.
University of California, Irvine · USUniversity of Southern California · USUniversity of Wisconsin–Madison · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Ultrafine Particulate Matter &Cardiorespiratory HealthR01ES012243 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DELFINO, RALPH J · 2003 to 2015
$6.0M
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NIEHS NIH HHS R01 ES012243
6 · The paper itself

Abstract

backgroundExposure to air pollution has been associated with cardiorespiratory morbidity and mortality. However, the chemical constituents and pollution sources underlying these associations remain unclear.

methodWe conducted a cohort panel study involving 97 elderly subjects living in the Los Angeles metropolitan area. Airway and circulating biomarkers of oxidative stress and inflammation were measured weekly over 12 weeks and included, exhaled breath condensate malondialdehyde (EBC MDA), fractional exhaled nitric oxide (FeNO), plasma oxidized low-density lipoprotein (oxLDL), and plasma interleukin-6 (IL-6). Exposures included 7-day personal nitrogen oxides (NOx), daily criteria-pollutant data, five-day average particulate matter (PM) measured in three size-fractions and characterized by chemical components including transition metals, and in vitro PM oxidative potential (dithiothreitol and macrophage reactive oxygen species). Associations between biomarkers and pollutants were assessed using linear mixed effects regression models.

resultsWe found significant positive associations of airway oxidative stress and inflammation with traffic-related air pollutants, ultrafine particles and transition metals. Positive but nonsignificant associations were observed with PM oxidative potential. The strongest associations were observed among PM variables in the ultrafine range (PM <0.18µm). It was estimated that an interquartile increase in 5-day average ultrafine polycyclic aromatic hydrocarbons was associated with a 6.3% (95% CI: 1.1%, 11.6%) increase in EBC MDA and 6.7% (95% CI: 3.4%, 10.2%) increase in FeNO. In addition, positive but nonsignificant associations were observed between oxLDL and traffic-related pollutants, ultrafine particles and transition metals while plasma IL-6 was positively associated with 1-day average traffic-related pollutants.

conclusionOur results suggest that exposure to pollutants with high oxidative potential (traffic-related pollutants, ultrafine particles, and transition metals) may lead to increased airway oxidative stress and inflammation in elderly adults. This observation was less clear with circulating biomarkers.

Indexed as

Environmental ExposureAgedAged, 80 and overAir PollutantsBiomarkersCohort StudiesFemaleFossil FuelsHumansInflammationLos AngelesMaleOxidative StressParticle SizeParticulate MatterAir PollutantsBiomarkersFossil FuelsParticulate MatterAir pollutionBiomarkersInflammationOxidative stressParticulate matter components

Identifiers

PMID27336235
PMCPMC5003670
OpenAlexW2465892421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.