ArticleFertility and sterility2016
Cancer risk in first- and second-degree relatives of men with poor semen quality.
Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Risk of non-reproductive cancer in men from couples conceiving through assisted reproduction: a Swedish nation-based register study.European journal of epidemiology · 2026Article
- The critical role of oxidative stress in male infertility: causes, diagnostic biomarkers, and the efficacy of antioxidant therapy.Molecular biology reports · 2026Review
- Neonatal characteristics of children conceived with in vitro fertilization or intrauterine insemination compared with sibling births from unassisted conceptions.Fertility and sterility · 2026Article
- Are infertile men at a higher risk of morbidity and early mortality?Human reproduction (Oxford, England) · 2026Review
- Risk of mortality in family members of men seeking fertility assessment.Fertility and sterility · 2025Article
- Azoospermia/Oligozoospermia and Prostate Cancer Are Increased in Families of Women With Primary Ovarian Insufficiency.Journal of the Endocrine Society · 2025Article
- Describing patterns of familial cancer risk in subfertile men using population pedigree data.Human reproduction (Oxford, England) · 2024Article
- Male Infertility and the Risk of Developing Testicular Cancer: A Critical Contemporary Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- The adverse role of endocrine disrupting chemicals in the reproductive system.Frontiers in endocrinology · 2023Review
- Shared genetics between nonobstructive azoospermia and primary ovarian insufficiency.F&S reviews · 2021Article
- Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database.Journal of assisted reproduction and genetics · 2021Article
- 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction.European thyroid journal · 2021Article
- Non-obstructive azoospermia: current and future perspectives.Faculty reviews · 2021Review
- Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of "big data".Fertility and sterility · 2020Review
- Urologic conditions associated with malignancy.Urologic oncology · 2020Review
- Mortality in 43,598 men with infertility - a Swedish nationwide population-based cohort study.Clinical epidemiology · 2019Article
- Recent advances in understanding and managing male infertility.F1000Research · 2019Review
- Testicular cancer.Nature reviews. Disease primers · 2018Review
- Limitations and opportunities in male fertility databases.Translational andrology and urology · 2018Review
- Genetic intersection of male infertility and cancer.Fertility and sterility · 2018Review
Corrections and comments
- Commented on by
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo further characterize the association of male infertility with health risks by evaluating semen quality and cancer risk in family members.
designRetrospective, cohort study.
settingNot applicable. PATIENT(S): A total of 12,889 men undergoing SA and 12,889 fertile control subjects that had first-degree relative (FDR) data (n = 130,689) and 8,032 men with SA and 8,032 fertile control subjects with complete second-degree relative (SDR) data (n = 247,204) were identified through the UPDB. An equal number of fertile population control subjects were matched.
interventionsNone. MAIN OUTCOME MEASURE(S): Adult all-site, testicular, thyroid, breast, prostate, melanoma, bladder, ovarian, and kidney cancer diagnoses in FDRs and SDRs. RESULT(S): The FDRs of men with SA had a 52% increased risk of testicular cancer compared with the FDRs of fertile population control subjects. There was no significant difference in testicular cancer risk for the SDRs based on any of the semen parameters. The FDRs and SDRs of azoospermic men had a significantly increased risk of thyroid cancer compared with fertile population control subjects. CONCLUSION(S): These data suggest a link between male infertility and selected cancer risk in relatives. This highlights the possibilities of shared biologic mechanisms between the two diseases, exposure to environmental factors, and an increased level of genetic and/or epigenetic burden in subfertile men and their relatives that may be associated with risk of cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.