Evidence map›Paper›PMID 27336042›Full record

ArticleNPJ schizophrenia2015

Does environmental confounding mask pleiotropic effects of a multiple sclerosis susceptibility variant on vitamin D in psychosis?

Conrad O Iyegbe, Anita Acharya, John Lally, Poonam Gardner-Sood, Louise S Smith, Shubulade Smith, Robin Murray, Oliver Howes, Fiona Gaughran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ schizophrenia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Conrad O IyegbeDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London, UK.
Anita AcharyaDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK; Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK.ORCID 0000-0003-4715-1837
John LallyDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK.
Poonam Gardner-SoodDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London, UK.
Louise S SmithKing's College London Dental Institute, Tower Wing, Guys Hospital , London, UK.
Shubulade SmithDepartment of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King's College London.
Robin MurrayDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London, UK.
Oliver HowesDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London, UK.
Fiona GaughranDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK ; Biomedical Research Centre, BRC Nucleus, Maudsley Hospital, South London and Maudsley NHS, London, UK.
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GBKing's College - North Carolina · USQueen Mary University of London · GB

Funding

Medical Research Council G0700995Medical Research Council MC_U120097115
6 · The paper itself

Abstract

backgroundThis work addresses the existing and emerging evidence of overlap within the environmental and genetic profiles of multiple sclerosis (MS) and schizophrenia.

aimsTo investigate whether a genetic risk factor for MS (rs703842), whose variation is indicative of vitamin D status in the disorder, could also be a determinant of vitamin D status in chronic psychosis patients.

methodsA cohort of 224 chronic psychosis cases was phenotyped and biologically profiled. The relationship between rs703842 and physiological vitamin D status in the blood plasma was assessed by logistic regression. Deficiency was defined as a blood plasma concentration below 10 ng/µl. Potential environmental confounders of the vitamin D status were considered as part of the analysis.

resultsWe report suggestive evidence of an association with vitamin D status in established psychosis (ß standardized=0.51, P=0.04). The logistic model fit significantly benefited from controlling for body mass index, depression and ethnicity (χ (2)=91.7; 2 degrees of freedom (df); P=1.2×10(20)).

conclusionsThe results suggest that, in addition to lifestyle changes that accompany the onset of illness, vitamin D dysregulation in psychosis has a genetic component that links into MS. Further, comprehensive studies are needed to evaluate this prospect.

Identifiers

PMID27336042
PMCPMC4849459
OpenAlexW1914029047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.