ArticleNPJ schizophrenia2015
Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register.
Article in NPJ schizophrenia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Prevalence of obsessive-compulsive symptoms in patients with schizophrenia treated with clozapine: a scoping review.BMC psychiatry · 2025Article
- Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia.Psychological medicine · 2018Article
- Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.Psychoneuroendocrinology · 2018Article
- FAM-FACE-SG: a score for risk stratification of frequent hospital admitters.BMC medical informatics and decision making · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of psychotropic drug choice upon admissions for schizophrenia is not well understood.
aimsTo examine the association between antipsychotic/antidepressant use and time in hospital for patients with schizophrenia.
methodsWe conducted an observational study, using 8 years' admission records and electronically generated drug histories from an institution providing secondary mental health care in Cambridgeshire, UK, covering the period 2005-2012 inclusive. Patients with a coded ICD-10 diagnosis of schizophrenia were selected. The primary outcome measure was the time spent as an inpatient in a psychiatric unit. Antipsychotic and antidepressant drugs used by at least 5% of patients overall were examined for associations with admissions. Periods before and after drug commencement were compared for patients having pre-drug admissions, in mirror-image analyses correcting for overall admission rates. Drug use in one 6-month calendar period was used to predict admissions in the next period, across all patients, in a regression analysis accounting for the effects of all other drugs studied and for time.
resultsIn mirror-image analyses, sulpiride, aripiprazole, clozapine, and olanzapine were associated with fewer subsequent admission days. In regression analyses, sulpiride, mirtazapine, venlafaxine, and clozapine-aripiprazole and clozapine-amisulpride combinations were associated with fewer subsequent admission days.
conclusionsUse of these drugs was associated with fewer days in hospital. Causation is not implied and these findings require confirmation by randomized controlled trials.
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