ArticleNPJ schizophrenia2015
Lower prefrontal activation during emotion regulation in subjects at ultrahigh risk for psychosis: an fMRI-study.
Article in NPJ schizophrenia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Neurophysiological evidence for emotion regulation abnormalities in individuals at clinical high-risk for psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Relationship Between Schizotypal Traits, Emotion Regulation, and Negative Affect in Children: A Network Analysis.Schizophrenia bulletin · 2025Article
- Deconstructing the nature of emotion regulation impairments at the identification, selection, and implementation stages in individuals at clinical high-risk for psychosis.Psychological medicine · 2025Article
- A Latent Profile Analysis of Emotion Regulation in Relation to Distress of Symptoms in Youth with Prodromal Psychotic Symptoms.Behavioral sciences (Basel, Switzerland) · 2024Article
- Paracingulate Sulcus Length and Cortical Thickness in Schizophrenia Patients With and Without a Lifetime History of Auditory Hallucinations.Schizophrenia bulletin · 2023Article
- Neural Correlates of Facial Emotion Recognition in Non-help-seeking University Students With Ultra-High Risk for Psychosis.Frontiers in psychology · 2022Article
- Structural and functional imaging markers for susceptibility to psychosis.Molecular psychiatry · 2020Review
- Neurophysiological evidence for emotion regulation impairment in schizophrenia: The role of visual attention and cognitive effort.Journal of abnormal psychology · 2020Article
- Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Stress during critical periods of development and risk for schizophrenia.Schizophrenia research · 2019Review
- Central serotonin modulates neural responses to virtual violent actions in emotion regulation networks.Brain structure & function · 2018Article
- The Relevance of Emotion Regulation in Explaining Why Social Exclusion Triggers Paranoia in Individuals at Clinical High Risk of Psychosis.Schizophrenia bulletin · 2018Article
- Weak dorsolateral prefrontal response to social criticism predicts worsened mood and symptoms following social conflict in people at familial risk for schizophrenia.NeuroImage. Clinical · 2018Article
- Effects of early trauma on psychosis development in clinical high-risk individuals and stability of trauma assessment across studies: a review.Archives of psychology (Chicago, Ill.) · 2017Article
- Prefrontal Cortex Dysfunction Increases Susceptibility to Schizophrenia-Like Changes Induced by Adolescent Stress Exposure.Schizophrenia bulletin · 2017Article
- Emotionally Neutral Stimuli Are Not Neutral in Schizophrenia: A Mini Review of Functional Neuroimaging Studies.Frontiers in psychiatry · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious research has shown that patients with schizophrenia experience difficulties with emotion regulation and activate prefrontal regions to a lesser extent during reappraisal of emotional information. It has been suggested that problems in emotion regulation might precede the onset of psychosis. Therefore, it could be hypothesized that also individuals at ultrahigh risk (UHR) for developing psychosis experience difficulties with emotion regulation.
aimsThe aim of the current study was to investigate whether individuals at UHR for developing psychosis show abnormal brain activation during reappraisal of negative pictures.
methodsUsing functional magnetic resonance imaging (fMRI), we scanned 15 UHR participants and 16 matched healthy controls while performing an emotion regulation task. During this task, participants had to reappraise their negative emotion elicited by International Affective Picture System pictures. Furthermore, the reported use of reappraisal was examined with the emotion regulation questionnaire (ERQ).
resultsIndividuals at UHR for psychosis showed less activation in the left ventrolateral prefrontal cortex during reappraisal compared with healthy controls. Furthermore, they reported less use of reappraisal in daily life (P=0.01; 95% CI (0.24-1.63)).
conclusionsThese findings indicate that dysfunctional emotion regulation may already occur in individuals at risk for psychosis. These regulation difficulties are underpinned by less ventrolateral prefrontal cortex activation, and may result in high negative affect, lower social functioning, and high rates of psychotic symptoms.
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