ReviewBeilstein journal of nanotechnology2016
Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms.
Review in Beilstein journal of nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Assessment of ion release, cytotoxicity, and potential systemic toxicity of titanium dental alloy.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- System-Dependent Ecotoxicological Effects of Anatase and Rutile Titanium Dioxide Nanoparticles Across Prokaryotic and Eukaryotic Test Models.Nanomaterials (Basel, Switzerland) · 2026Article
- Glia Cells Are Selectively Sensitive to Nanosized Titanium Dioxide Mineral Forms.International journal of molecular sciences · 2025Article
- Multigenerational inheritance of breathing deficits following perinatal exposure to titanium dioxide nanoparticles in the offspring of mice.Discover nano · 2024Article
- Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.Brain : a journal of neurology · 2023Review
- The use of nanoparticles in the treatment of infectious diseases and cancer, dental applications and tissue regeneration: a review.Frontiers in medical technology · 2023Review
- A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk.Journal of neurology · 2022Review
- Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases.International journal of nanomedicine · 2022Review
- Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology.Pharmacology research & perspectives · 2021Review
- Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology.Journal of toxicology · 2021Review
- Emerging Nanotechnology for Treatment of Alzheimer's and Parkinson's Disease.Frontiers in bioengineering and biotechnology · 2021Review
- Titanium dioxide nanoparticles via oral exposure leads to adverse disturbance of gut microecology and locomotor activity in adult mice.Archives of toxicology · 2020Article
- Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1.Nanoscale research letters · 2020Article
- Biphasic adverse effect of titanium nanoparticles on testicular function in mice.Scientific reports · 2019Article
- The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra.Iranian journal of basic medical sciences · 2019Article
- Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats.Molecular biology reports · 2019Article
- Neurotoxicity of Nanomaterials: An Up-to-Date Overview.Nanomaterials (Basel, Switzerland) · 2019Review
- The neurotoxicity induced by engineered nanomaterials.International journal of nanomedicine · 2019Review
- Hepatic and Renal Toxicity Induced by TiOJournal of toxicology · 2019Article
- Impact of Nanoparticles on Brain Health: An Up to Date Overview.Journal of clinical medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide nanoparticles (TiO2 NPs) possess unique characteristics and are widely used in many fields. Numerous in vivo studies, exposing experimental animals to these NPs through systematic administration, have suggested that TiO2 NPs can accumulate in the brain and induce brain dysfunction. Nevertheless, the exact mechanisms underlying the neurotoxicity of TiO2 NPs remain unclear. However, we have concluded from previous studies that these mechanisms mainly consist of oxidative stress (OS), apoptosis, inflammatory response, genotoxicity, and direct impairment of cell components. Meanwhile, other factors such as disturbed distributions of trace elements, disrupted signaling pathways, dysregulated neurotransmitters and synaptic plasticity have also been shown to contribute to neurotoxicity of TiO2 NPs. Recently, studies on autophagy and DNA methylation have shed some light on possible mechanisms of nanotoxicity. Therefore, we offer a new perspective that autophagy and DNA methylation could contribute to neurotoxicity of TiO2 NPs. Undoubtedly, more studies are needed to test this idea in the future. In short, to fully understand the health threats posed by TiO2 NPs and to improve the bio-safety of TiO2 NPs-based products, the neurotoxicity of TiO2 NPs must be investigated comprehensively through studying every possible molecular mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.