Evidence map›Paper›PMID 27335693›Full record

ArticleInternational journal of burns and trauma2016

Burn trauma disrupts circadian rhythms in rat liver.

Rohit Rao, Qian Yang, Mehmet A Orman, Francois Berthiaume, Marianthi G Ierapetritou, Ioannis P Androulakis

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of burns and trauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rohit RaoChemical and Biochemical Engineering Department, Rutgers, The State University of New Jersey Piscataway, NJ 08854, USA.
Qian YangChemical and Biochemical Engineering Department, Rutgers, The State University of New Jersey Piscataway, NJ 08854, USA.
Mehmet A OrmanChemical and Biochemical Engineering Department, Rutgers, The State University of New Jersey Piscataway, NJ 08854, USA.
Francois BerthiaumeBiomedical Engineering Department, Rutgers, The State University of New Jersey Piscataway, NJ 08854, USA.
Marianthi G IerapetritouChemical and Biochemical Engineering Department, Rutgers, The State University of New Jersey Piscataway, NJ 08854, USA.
Ioannis P AndroulakisChemical and Biochemical Engineering Department, Rutgers, The State University of New JerseyPiscataway, NJ 08854, USA; Biomedical Engineering Department, Rutgers, The State University of New JerseyPiscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · US

Funding

Bioinformatics Analysis of Control Mechanisms of HypermetabolismR01GM082974 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANDROULAKIS, IOANNIS P · 2008 to 2011
$1.6M
NIGMS NIH HHS R01 GM082974
6 · The paper itself

Abstract

Circadian rhythms play an important role in maintaining homeostasis and solid organ function. The purpose of this study is to assess the implications of burn injury in rats on the underlying circadian patterns of gene expression in liver. Circadian-regulated genes and burn-induced genes were identified by applying consensus clustering methodology to temporally differentially expressed probe sets obtained from burn and sham-burn data sets. Of the liver specific genes which we hypothesize that exhibit circadian rhythmicity, 88% are not differentially expressed following the burn injury. Specifically, the vast majority of the circadian regulated-genes representing central carbon and nitrogen metabolism are "up-regulated" after the burn injury, indicating the onset of hypermetabolism. In addition, cell-cell junction and membrane structure related genes showing rhythmic behavior in the control group were not differentially expressed across time in the burn group, which could be an indication of hepatic damage due to the burn. Finally, the suppression of the immune function related genes is observed in the postburn phase, implying the severe "immunosuppression". Our results demonstrated that the short term response (24-h post injury) manifests a loss of circadian variability possibly compromising the host in terms of subsequent challenges.

Indexed as

burn injuryCircadian clockdifferentially expressed gene clusterslivermicroarray analysisrats

Identifiers

PMID27335693
PMCPMC4913229
OpenAlexW2469166494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.