Evidence map›Paper›PMID 27335651›Full record

ArticleBMJ open respiratory research2016

Exploratory study into the effect of abdominal mass loading on airways resistance and ventilatory failure.

Raj S Dattani, Casey B Swerner, John R Stradling, Ari Rg Manuel

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01380418 (Factors Associated With Chronic Respiratory Failure in Obesity), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01380418 completednot on this map

Factors Associated With Chronic Respiratory Failure in Obesity: A Cross-sectional Study

TypeobservationalSponsorOxford University Hospitals NHS TrustRan2011 to 2015Enrolled78ConditionsObesity, Obesity Hypoventilation Syndrome
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Reference equations for oscillometry and their differences among populations: a systematic scoping review.European respiratory review : an official journal of the European Respiratory Society · 2022
    Article
  4. Clinical significance and applications of oscillometry.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  5. Article
  6. Article
  7. Small Airway Disease Syndromes. Piercing the Quiet Zone.Annals of the American Thoracic Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Raj S DattaniOxford Respiratory Trials Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, UK; St Peter's College, New Inn Hall Street, Oxford, UK; Centre for Altitude, Space and Extreme Environment Medicine (CASE Medicine), Institute of Sport Exercise and Health, University College London, London, UK.
Casey B SwernerUniversity College London , London , UK.
John R StradlingOxford Respiratory Trials Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Centre for Respiratory Medicine, NIHR Oxford Biomedical Research Centre, The Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Ari Rg ManuelOxford Respiratory Trials Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Centre for Respiratory Medicine, NIHR Oxford Biomedical Research Centre, The Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
Churchill Hospital · GBSt Peter's Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe hypothesised that the airway resistance during tidal breathing would correlate with a particular pattern of increasing obesity, particularly when supine, and would differ between participants with and without ventilatory failure.

methodsIn our cross-sectional cohort study, 72 morbidly obese patients (40 males, 32 females, mean body mass index (BMI) 47.2) had measurements of both airways resistance (by impulse oscillometry (IOS)) and adiposity (by dual-energy X-ray absorptiometry (DXA)).

resultsAll measures of airways resistance increased in the supine position: total airways resistance (R5) +37% (p<0.0005); large airways resistance (R20) +29% (p<0.0005); and small airways resistance (R5-R20) +52% (p<0.0005). BMI was correlated with seated R5, seated R5-R20, supine R5 and supine R5-R20 (r=0.33 p<0.006, r=0.32 p<0.004, r=0.30 p<0.02 and r=0.36 p<0.04, respectively). Visceral adipose tissue mass was correlated with supine R5-20 (r=0.46 p<0.05). Supine measures of total airways resistance (R5) and large airways resistance (R20) differed between those with and without ventilatory failure, as did mean weight and BMI.

conclusionsOur study identifies a potentially detrimental effect of the supine posture on tidal breathing airways resistance in obese patients. This change is correlated most with visceral adipose tissue mass and the small airways. We were able to demonstrate that supine increases in airways resistance during tidal breathing, within obese patients, are different between those with and without ventilatory failure. TRIAL REGISTRATION NUMBER: NCT01380418; pre-results.

Indexed as

Lung PhysiologyRespiratory Measurement

Identifiers

PMID27335651
PMCPMC4908953
OpenAlexW2417597932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.