ArticleOpen access Macedonian journal of medical sciences2016
Expression Levels of Some Detoxification Genes in Liver and Testis of Rats Exposed to a Single Dose of Methyl-Tertiary Butyl Ether.
Article in Open access Macedonian journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Genotoxicity effect of methyl-tertiary butyl ether on rat lymphocytes using comet assay.EXCLI journal · 2020Article
- Effects of Acute and Sub-chronic Exposure to Low Doses of Methyl-tertiary Butyl Ether on mRNA Levels of Three Members of Glutathione S-transferases in Liver and Testis of the Male Rats.Iranian journal of public health · 2018Article
- Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression.Environmental health and preventive medicine · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimMethyl-tertiary-butyl ether (MTBE), a well-known gasoline oxygenate compound, is still used in several countries. Several studies investigated the effects of MTBE on the activity of phase II metabolism enzymes. There is no published data on the effect(s) of short-term exposure to MTBE on mRNA levels of antioxidant genes. Therefore, the present study was carried out.
methodsA total of 15 adults male Wistar rats were randomly divided into five equal experimental groups. They received a single dose of 0, 400, 800 and 1600 mg/Kg MTBE in peanut oil by gavages. The final group received no MTBE and peanut oil. After 24 hr animals were slaughtered then livers and testis were removed to extract the total RNA. Real-time PCR was done to detect the gene expressions of glutathione S-transferase family (Gstt1, Gstm1, and Gstp1).
resultsThe mRNAs levels of the examined genes neither in liver nor in testis showed a significant difference between the exposed groups and control rats.
conclusionsThe present data revealed that exposure to a single dose of MTBE has no significant effect on the mRNA levels of the Gstt1, Gstm1, and Gstp1 genes.
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