ArticleProceedings of the National Academy of Sciences of the United States of America2016
Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Lysine Acetyltransferase 6 in Health and Disease.MedComm · 2025Review
- Jawbone-like organoids generated from human pluripotent stem cells.Nature biomedical engineering · 2025Article
- Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.PloS one · 2025Article
- Article
- Temporally resolved early BMP-driven transcriptional cascade during human amnion specification.bioRxiv : the preprint server for biology · 2024Article
- In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells.Nature communications · 2024Article
- Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.Frontiers in cell and developmental biology · 2024Article
- Fibronectin and Hand2 influence tubulogenesis during pronephros development and mesonephros regeneration in zebrafish (Danio rerio).PloS one · 2024Article
- Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis.Development (Cambridge, England) · 2023Article
- TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.eLife · 2022Article
- Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development.International journal of molecular sciences · 2021Article
- GATA3 is essential for separating patterning domains during facial morphogenesis.Development (Cambridge, England) · 2021Article
- HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Developmental biology · 2021Article
- The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage.International journal of molecular sciences · 2021Review
- Deletion of aJournal of cardiovascular development and disease · 2021Article
- Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.Biology open · 2020Article
- Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes.Journal of cardiovascular development and disease · 2020Article
- Partially Penetrant Cardiac Neural Crest Defects in Hand1 Phosphomutant Mice: Dimer Choice That Is Not So Critical.Pediatric cardiology · 2019Review
- Article
- Hand Factors in Cardiac Development.Anatomical record (Hoboken, N.J. : 2007) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Cranial neural crest cells (crNCCs) migrate from the neural tube to the pharyngeal arches (PAs) of the developing embryo and, subsequently, differentiate into bone and connective tissue to form the mandible. Within the PAs, crNCCs respond to local signaling cues to partition into the proximo-distally oriented subdomains that convey positional information to these developing tissues. Here, we show that the distal-most of these subdomains, the distal cap, is marked by expression of the transcription factor Hand1 (H1) and gives rise to the ectomesenchymal derivatives of the lower incisors. We uncover a H1 enhancer sufficient to drive reporter gene expression within the crNCCs of the distal cap. We show that bone morphogenic protein (BMP) signaling and the transcription factor HAND2 (H2) synergistically regulate H1 distal cap expression. Furthermore, the homeodomain proteins distal-less homeobox 5 (DLX5) and DLX6 reciprocally inhibit BMP/H2-mediated H1 enhancer regulation. These findings provide insights into how multiple signaling pathways direct transcriptional outcomes that pattern the developing jaw.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.