ArticleJournal of experimental botany2016
The PSE1 gene modulates lead tolerance in Arabidopsis.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- RsWRKY15-RsPDR12 module regulates Cd uptake and accumulation by promoting Cd efflux in radish (Raphanus sativus L.).Molecular horticulture · 2026Article
- Underlying mechanism of Dendrobium huoshanense resistance to lead stress using the quantitative proteomics method.BMC plant biology · 2024Article
- Genome-wide identification and characterization of NAC transcription factor family members in Trifolium pratense and expression analysis under lead stress.BMC genomics · 2024Article
- Polychlorinated biphenyls modifyFrontiers in plant science · 2024Article
- Pb Transfer Preference of Arbuscular Mycorrhizal FungusJournal of fungi (Basel, Switzerland) · 2022Article
- MNB1 gene is involved in regulating the iron-deficiency stress response in Arabidopsis thaliana.BMC plant biology · 2022Article
- Overexpression ofFrontiers in plant science · 2022Article
- Association mapping uncovers maizeFrontiers in plant science · 2022Article
- Proteomic analysis ofFrontiers in plant science · 2022Article
- Genome-Wide Association Study Reveals Key Genes for Differential Lead Accumulation and Tolerance in NaturalFrontiers in plant science · 2021Article
- Molecular Interaction and Evolution of Jasmonate Signaling With Transport and Detoxification of Heavy Metals and Metalloids in Plants.Frontiers in plant science · 2021Review
- Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches.International journal of environmental research and public health · 2020Review
- Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids.Frontiers in plant science · 2020Review
- Negative regulation of cadmium tolerance in Arabidopsis by MMDH2.Plant molecular biology · 2019Article
- AtPID: a genome-scale resource for genotype-phenotype associations in Arabidopsis.Nucleic acids research · 2017Article
- Transcriptomic and physiological analyses of Medicago sativa L. roots in response to lead stress.PloS one · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb) is a dangerous heavy metal contaminant with high toxicity to plants. However, the regulatory mechanism of plant Pb tolerance is poorly understood. Here, we showed that the PSE1 gene confers Pb tolerance in Arabidopsis. A novel Pb-sensitive mutant pse1-1 (Pb-sensitive1) was isolated by screening T-DNA insertion mutants. PSE1 encodes an unknown protein with an NC domain and was localized in the cytoplasm. PSE1 was induced by Pb stress, and the pse1-1 loss-of-function mutant showed enhanced Pb sensitivity; overexpression of PSE1 resulted in increased Pb tolerance. PSE1-overexpressing plants showed increased Pb accumulation, which was accompanied by the activation of phytochelatin (PC) synthesis and related gene expression. In contrast, the pse1-1 mutant showed reduced Pb accumulation, which was associated with decreased PC synthesis and related gene expression. In addition, the expression of PDR12 was also increased in PSE1-overexpressing plants subjected to Pb stress. Our results suggest that PSE1 regulates Pb tolerance mainly through glutathione-dependent PC synthesis by activating the expression of the genes involved in PC synthesis and at least partially through activating the expression of the ABC transporter PDR12/ABCG40.
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