Evidence map›Paper›PMID 27335364›Full record

ArticleBMJ case reports2016

Challenges in a large mixed drug overdose patient.

Paige Zhang, Emily Austin, Margaret Thompson, Steve Lin

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paige ZhangUniversity of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-8727-149X
Emily AustinUniversity of Toronto, Toronto, Ontario, Canada Department of Emergency Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
Margaret ThompsonUniversity of Toronto, Toronto, Ontario, Canada Department of Emergency Medicine, St. Michael's Hospital, Toronto, Ontario, Canada Ontario Poison Centre, Sick Kids Hospital, Toronto, Ontario, Canada.
Steve LinUniversity of Toronto, Toronto, Ontario, Canada Department of Emergency Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 39-year-old homeless man was found confused and incoherent after ingesting an estimated total of 200 tablets of various medications. He presented to the emergency department with delirium, tachycardia, clonus and hyperthermia of 38.0°C. His condition worsened rapidly with his temperature rising to 39.9°C despite active cooling. The patient was subsequently sedated, intubated, paralysed and admitted to the intensive care unit, where he remained for 38 days. His initial presentation of a large mixed drug overdose manifested as serotonin syndrome, which had a protracted course complicated by ethanol withdrawal. He eventually stabilised and was transferred to the general ward, and was subsequently discharged from hospital on day 47 with continuing psychiatric care. This case demonstrates the challenges and considerations in diagnosis and management of large mixed drug overdoses where multiple toxidromes overlap.

Indexed as

Critical CarePrescription Drug MisuseAdultAnticonvulsantsBody Temperature RegulationDeliriumDiazepamDrug OverdoseFeverHumansHypnotics and SedativesMaleMidazolamSerotonin SyndromeSubstance Withdrawal SyndromeTime FactorsAnticonvulsantsDiazepamHypnotics and SedativesMidazolam

Identifiers

PMID27335364
PMCPMC4932329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.