ArticleBMJ case reports2016
Delirium with anticholinergic symptoms after a combination of paliperidone and olanzapine pamoate in a patient known to smoke cannabis: an unfortunate coincidence.
Article in BMJ case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report.BMC psychiatry · 2023Article
- Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.Frontiers in aging neuroscience · 2022Article
- Cannabinoids for the treatment of rheumatic diseases - where do we stand?Nature reviews. Rheumatology · 2018Review
- Paliperidone Palmitate-Induced Delirium in an Adolescent with Schizophrenia: Case report.Sultan Qaboos University medical journal · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
We report a case of delirium with anticholinergic symptoms in a 19-year-old female patient with schizophrenia. On the day the symptoms emerged, the patient received olanzapine long-acting injection and a higher dose of paliperidone. We observed symptoms ranging from confusion to delirium as well as some anticholinergic symptoms. The delirium lasted 24 hours and was managed by intravenous fluid substitution and oral benzodiazepines. Olanzapine pamoate, paliperidone and cannabis are central nervous system (CNS) depressants, and their combination can increase the risks of CNS depression. In this case report, we review the symptoms of delirium in a case of antipsychotic overdose and provide general guidelines for managing these symptoms. We also review possible complications in combined use of cannabis, olanzapine and paliperidone.
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