ReviewJournal of the Royal Society, Interface2016
Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils.
Review in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders.Frontiers in endocrinology · 2020Pooled it
- Bone histological evidence for posture-related load transmission in the talpid pectoral girdle.Journal of anatomy · 2026Article
- Combination of 3D and 2D Small and Wide Angle X-Ray Scattering Imaging Reveals Diminished Bone Quality in the Superior Human Femoral Neck Cortex.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Three-Dimensional Characterization of the Collagen-Hydroxyapatite Interaction During Heterotopic Ossification in Healing Rat Achilles Tendons.Small science · 2026Article
- Interdisciplinarity of secondary osteons: relevance of bioarchaeological and palaeontological research in biomedical cortical bone histology studies.Bone reports · 2026Review
- A 50-year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Adhesive-Electrocoupling Hydrogels for Tissue Regeneration: Design, Mechanisms, and Perspectives.Research (Washington, D.C.) · 2026Review
- Demonstration of a novel method to explore osteon tilt in the human femoral cortex.Scientific reports · 2025Article
- Interpreting synchrotron infrared nano-spectra of hydroxyapatite through Kramers-Kronig relations and complex Lorentzian oscillators.Scientific reports · 2025Article
- Article
- Medusa's gaze: Cell traces and fibrils but no collagen in permineralized Jurassic ichthyosaur bone.iScience · 2025Article
- Characterization of human trabecular bone across multiple length scales using a correlative approach combining X-ray tomography with LaserFIB and plasma FIB-SEM.Scientific reports · 2024Article
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- Keratin from Animal By-Products: Structure, Characterization, Extraction and Application-A Review.Polymers · 2024Review
- In vivo imaging of bone collagen dynamics in zebrafish.Bone reports · 2024Article
- A novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineering.Frontiers in medicine · 2024Article
- Ultrastructure and Nanoporosity of Human Bone Shown with Correlative On-Axis Electron and Spectroscopic Tomographies.ACS nano · 2023Article
- Small-angle scattering tensor tomography algorithm for robust reconstruction of complex textures.Acta crystallographica. Section A, Foundations and advances · 2023Article
- Hierarchical Structure and Properties of the Bone at Nano Level.Bioengineering (Basel, Switzerland) · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone's remarkable mechanical properties are a result of its hierarchical structure. The mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's building blocks at an ultrastructural level. The organization of bone's ultrastructure with respect to the orientation and arrangement of mineralized collagen fibrils has been the matter of numerous studies based on a variety of imaging techniques in the past decades. These techniques either exploit physical principles, such as polarization, diffraction or scattering to examine bone ultrastructure orientation and arrangement, or directly image the fibrils at the sub-micrometre scale. They make use of diverse probes such as visible light, X-rays and electrons at different scales, from centimetres down to nanometres. They allow imaging of bone sections or surfaces in two dimensions or investigating bone tissue truly in three dimensions, in vivo or ex vivo, and sometimes in combination with in situ mechanical experiments. The purpose of this review is to summarize and discuss this broad range of imaging techniques and the different modalities of their use, in order to discuss their advantages and limitations for the assessment of bone ultrastructure organization with respect to the orientation and arrangement of mineralized collagen fibrils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.