ArticleBiology of reproduction2016
SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice.
Article in Biology of reproduction, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Amhy/Amhr2y-mediated sex determination in two distantly related teleosts relies on the conserved Alk3-Smad5 axis.Molecular biology and evolution · 2026Article
- Article
- Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Review
- Differentially Expressed Candidate miRNAs of Day 16 Bovine Embryos on the Regulation of Pregnancy Establishment in Dairy Cows.Animals : an open access journal from MDPI · 2023Article
- Single-step genome-wide association studies and post-GWAS analyses for the number of oocytes and embryos in Gir cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Assessment ofInternational journal of molecular sciences · 2023Article
- SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration.Communications biology · 2023Article
- Optical coherence tomography for dynamic investigation of mammalian reproductive processes.Molecular reproduction and development · 2023Review
- Expression and Polymorphisms ofGenes · 2022Article
- Molecular Characterization, Expression Profiles ofAnimals : an open access journal from MDPI · 2022Article
- BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy.Endocrinology · 2022Article
- Decidualization and Related Pregnancy Complications.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
- Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.Nature communications · 2021Article
- Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling.Biology of reproduction · 2021Article
- Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract.Scientific reports · 2021Article
- A First Insight into the Gonad Transcriptome of Hong Kong Catfish (Animals : an open access journal from MDPI · 2021Article
- Genes and Pathways Affecting Sheep Productivity Traits: Genetic Parameters, Genome-Wide Association Mapping, and Pathway Enrichment Analysis.Frontiers in genetics · 2021Article
- Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein.Environmental health perspectives · 2020Article
- MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pregnancy is a complex physiological process tightly controlled by the interplay among hormones, morphogens, transcription factors, and signaling pathways. Although recent studies using genetically engineered mouse models have revealed that ligands and receptors of transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) signaling pathways are essential for multiple reproductive events during pregnancy, the functional role of SMAD transcription factors, which serve as the canonical signaling platform for the TGFbeta/BMP pathways, in the oviduct and uterus is undefined. Here, we used a mouse model containing triple conditional deletion of the BMP receptor signaling Smads (Smad1 and Smad5) and Smad4, the central mediator of both TGFbeta and BMP signaling, to investigate the role of the SMADs in reproductive tract structure and function in cells from the Amhr2 lineage. Unlike the respective single- or double-knockouts, female Smad1(flox/flox) Smad5(flox/flox) Smad4(flox/flox) Amhr2(cre/+)conditional knockout (i.e., Smad1/5/4-Amhr2-cre KO) mice are sterile. We discovered that Smad1/5/4-Amhr2-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. These oviducts showed dysregulation of multiple genes essential for oviduct and smooth muscle development. In addition, uteri from Smad1/5/4-Amhr2-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation. Taken together, our study uncovers a new role for the SMAD transcription factors in maintaining the structural and functional integrity of oviduct and uterus, required for establishment and maintenance of pregnancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.