ArticleMedical mycology2016
HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo.
Article in Medical mycology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Article
- How Histoplasma Evades the Human Immune System.Acta medica academica · 2025Review
- Tools for genetic manipulation of the endemic fungal pathogen,bioRxiv : the preprint server for biology · 2025Article
- Elevated carbon dioxide enhances the growth and reduces the antifungal susceptibility ofMicrobiology spectrum · 2025Article
- Article
- The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024Review
- Genotypic diversity, virulence, and molecular genetic tools inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Influence of Zinc onJournal of fungi (Basel, Switzerland) · 2024Article
- Utilization of amSphere · 2024Article
- A novel zinc-chelating compound has antifungal activity against a wide range ofJAC-antimicrobial resistance · 2024Article
- Zinc Starvation Induces Cell Wall Remodeling and Activates the Antioxidant Defense System inJournal of fungi (Basel, Switzerland) · 2024Article
- How metals fuel fungal virulence, yet promote anti-fungal immunity.Disease models & mechanisms · 2023Review
- Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?Infection and immunity · 2023Review
- Article
- Histoplasma capsulatum Relies on Tryptophan Biosynthesis To Proliferate within the Macrophage Phagosome.Infection and immunity · 2023Article
- Pathogenicity & virulence ofVirulence · 2022Review
- Mac1-Dependent Copper Sensing PromotesmBio · 2022Article
- Nutritional immunity: targeting fungal zinc homeostasis.Heliyon · 2021Review
- Cation Transporters ofBiomolecules · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Histoplasma capsulatum (Hc) exists in the soil and is capable of adapting to the shift in environment during infection to ensure survival. Yeast encounter a restrictive host environment low in nutrients such as zinc. In this study we functionally analyzed a putative zinc regulated transporter, HcZrt2, in zinc limiting conditions by complementation of HcZrt2 and gene knockdown through RNA interference (RNAi). Complementation analysis demonstrated HcZrt2's ability to functionally replace the characterized Saccharomyces cerevisiae zinc plasma membrane transporters Zrt1 and Zrt2 in zinc deficient medium. Gene silencing revealed that HcZrt2 is essential for growth in zinc deficient medium and plays a role in zinc accumulation. Fungal burden was reduced in mice infected with HcZrt2 silenced strains compared to a control strain. Sixty-seven percent of mice infected with a lethal dose of HcZrt2-RNAi#1 survived, and 100% of mice infected with HcZrt2-RNAi#2 withstood lethal infection. Our data suggest that HcZrt2 is a vital part of zinc homeostasis and essential for the pathogenesis of histoplasmosis.
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