ReviewMalaria journal2016
Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives.
Review in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Kaposi's Sarcoma: A Non-Communicable Outcome Mainly Prompted by Communicable Diseases in Sub-Saharan Africa.International journal of molecular sciences · 2025Review
- The role of breastfeeding, antibiotics and antimalarial medicinal exposure in paediatric depression amongst children aged under 5: a population-based study.BMC pediatrics · 2025Article
- Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria.Scientific reports · 2024Article
- The human malaria-Antimicrobial agents and chemotherapy · 2024Review
- Microbes and Mental Illness: Past, Present, and Future.Healthcare (Basel, Switzerland) · 2023Review
- The need to promote sleep health in public health agendas across the globe.The Lancet. Public health · 2023Review
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- Prevalence of early postpartum depression and associated risk factors among selected women in southern Malawi: a nested observational study.BMC pregnancy and childbirth · 2023Observational
- Chloroquine-Induced Psychosis: A Case Report.Cureus · 2022Article
- Collaboration between Psychiatrists and Other Allied Medical Specialists for the Treatment of Delusional Disorders.Healthcare (Basel, Switzerland) · 2022Review
- Strengthening therapeutic adherence and pharmacovigilance to antimalarial treatment in Manaus, Brazil: a multicomponent strategy using mHealth.Malaria journal · 2022Article
- Recommendations for the care of patients with bipolar disorder during the COVID-19 pandemic.Journal of affective disorders · 2021Review
- AZD9291 Resistance Reversal Activity of a pH-Sensitive Nanocarrier Dual-Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Antimalarial activity of basic phospholipases AToxicon: X · 2020Article
- Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity.iScience · 2020Article
- The COVID-19 pandemic is a crisis and opportunity for bipolar disorder.Bipolar disorders · 2020Article
- Hydroxychloroquine and chloroquine for COVID-19: psychiatric aspects of patient safety considerations.Therapeutic advances in drug safety · 2020Article
- Mapping the perturbome network of cellular perturbations.Nature communications · 2019Article
- Psychosis consequent to antimalarial drug use in a young child.Journal of family medicine and primary care · 2019Article
- The past, present and future of anti-malarial medicines.Malaria journal · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders of personality, mood, memory, attention, thought, and behaviour. In this article, the history of psychiatric effects attributed to malaria and post-malaria syndromes is reviewed, and insights from the historical practice of malariotherapy in contributing to understanding of these effects are considered. This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.