ArticleSurgical endoscopy2017
Biologic mesh for repair of ventral hernias in contaminated fields: long-term clinical and patient-reported outcomes.
Article in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevention of incisional hernia at the site of stoma closure with different reinforcing mesh types: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2021Pooled it
- Comparison of short-term clinical efficacy and safety between biological and synthetic meshes in laparoscopic hiatal hernia repair: a single-center randomized controlled trial.Hernia : the journal of hernias and abdominal wall surgery · 2025Trial
- Regeneration of the Gastrointestinal Tract After Using a Small Intestine Submucosa Patch-A Rat Model.Biomedicines · 2025Article
- Readmissions after emergent incisional ventral hernia repair: a retrospective review of the nationwide readmissions database.Updates in surgery · 2023Article
- Implantation of biologic mesh in ventral hernia repair-does it make sense?Surgical endoscopy · 2021Article
- Single-stage repair of contaminated hernias using a novel antibiotic-impregnated biologic porcine submucosa tissue matrix.BMC surgery · 2020Observational
- Nano-biological mesh constructed by astragaloside-IV-induced bone marrow mesenchymal stem cells on PLGA-NPs-SIS can be used for abdominal wall reconstruction.American journal of translational research · 2020Article
- Retromuscular Mesh Repair Using Fibrin Glue: Early Outcomes and Cost-effectiveness of an Evolving Technique.Plastic and reconstructive surgery. Global open · 2019Article
- Systematic review of the stage of innovation of biological mesh for complex or contaminated abdominal wall closure.BJS open · 2018Review
- [Rare cause of right-sided lower abdominal pain].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
- What is the evidence for the use of biologic or biosynthetic meshes in abdominal wall reconstruction?Hernia : the journal of hernias and abdominal wall surgery · 2018Review
- Prospective study of single-stage repair of contaminated hernias with the novel use of calcium sulphate antibiotic beads in conjunction with biologic porcine submucosa tissue graft.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines recommend biologic prosthetics for ventral hernia repair (VHR) in contaminated fields, yet long-term and patient-reported data are limited. We aimed to determine the long-term rate of hernia recurrence, and other clinical and patient-reported outcomes following the use of porcine small intestine submucosa (PSIS) for VHR in a contaminated field.
methodsConsecutive patients undergoing open VHR with PSIS mesh in a contaminated field from 2004 to 2014 were prospectively evaluated for hernia recurrence and other post-operative complications. Multivariate logistic and Cox regression analyses identified predictors of hernia recurrence and surgical site infection. Patient-reported outcomes were evaluated using SF-36, Hernia-Related Quality-of-Life Survey (HerQLes) and Body Image Questionnaire instruments.
resultsForty-six hernias were repaired in clean-contaminated [16 (35 %)], contaminated [11 (24 %)] and dirty [19 (41 %)] fields. Median follow-up was 47 months [interquartile range: 31-79] and all patients had greater than 12-month follow-up. Sixteen patients (35 %) were not re-examined. Incidence of surgical site events and surgical site infection were 43 % (n = 20) and 56 % (n = 25), respectively. American Society of Anesthesiologists score 3 or greater was an independent predictor of surgical site infection (odds ratio 5.34 [95 % confidence interval 1.01-41.80], p = 0.04). Hernia recurrence occurred in 61 % (n = 28) with a median time to diagnosis of 16 months [interquartile range 8-26]. After bridged repair, 16 of 18 patients (89 %) recurred, compared to 12 of 28 (43 %) when fascia was approximated (p < 0.01). Bridged repair was an independent predictor of recurrence (odds ratio 10.67 [95 % confidence interval 2.42-76.08], p < 0.01). Patients with recurrences had significantly worse scores on the SF-36 mental health component and self-perceived body image, whereas HerQLes scores were similar.
conclusionsHernia recurrences and wound infections are high with the use of biologic PSIS mesh in contaminated surgical fields. Careful consideration is warranted using this approach.
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