ArticleJournal of neurophysiology2016
Target-specific M1 inputs to infragranular S1 pyramidal neurons.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.Brain structure & function · 2026Review
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Functional Connectivity Between Human Motor and Somatosensory Areas During a Multifinger Tapping Task: A Proof-of-Concept Study.NeuroSci · 2026Article
- Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery.NeuroImage. Clinical · 2025Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Article
- Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Post-Ischemic Reorganization of Sensory Responses in Cerebral Cortex.bioRxiv : the preprint server for biology · 2023Article
- Post-ischemic reorganization of sensory responses in cerebral cortex.Frontiers in neuroscience · 2023Article
- Sensorimotor performance after high-definition transcranial direct current stimulation over the primary somatosensory or motor cortices in men versus women.Scientific reports · 2022Article
- Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction.Neural regeneration research · 2022Article
- Short-Term Facilitation of Long-Range Corticocortical Synapses Revealed by Selective Optical Stimulation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A Cortico-Cortical Pathway Targets Inhibitory Interneurons and Modulates Paw Movement during Locomotion in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The synaptic inputs and thalamic projections of two classes of layer 6 corticothalamic neurons in primary somatosensory cortex of the mouse.The Journal of comparative neurology · 2021Article
- Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.Science advances · 2021Article
- Reduction of corpus callosum activity during whisking leads to interhemispheric decorrelation.Nature communications · 2021Article
Corrections and comments
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3 authors.
Funding
Abstract
The functional role of input from the primary motor cortex (M1) to primary somatosensory cortex (S1) is unclear; one key to understanding this pathway may lie in elucidating the cell-type specific microcircuits that connect S1 and M1. Recently, we discovered that a subset of pyramidal neurons in the infragranular layers of S1 receive especially strong input from M1 (Kinnischtzke AK, Simons DJ, Fanselow EE. Cereb Cortex 24: 2237-2248, 2014), suggesting that M1 may affect specific classes of pyramidal neurons differently. Here, using combined optogenetic and retrograde labeling approaches in the mouse, we examined the strengths of M1 inputs to five classes of infragranular S1 neurons categorized by their projections to particular cortical and subcortical targets. We found that the magnitude of M1 synaptic input to S1 pyramidal neurons varies greatly depending on the projection target of the postsynaptic neuron. Of the populations examined, M1-projecting corticocortical neurons in L6 received the strongest M1 inputs, whereas ventral posterior medial nucleus-projecting corticothalamic neurons, also located in L6, received the weakest. Each population also possessed distinct intrinsic properties. The results suggest that M1 differentially engages specific classes of S1 projection neurons, thereby regulating the motor-related influence S1 exerts over subcortical structures.
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