ArticleJournal of neurophysiology2016
Optogenetic manipulation of neural circuits in awake marmosets.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.Cell reports methods · 2026Article
- Neural Recording Chambers for Long-Term Access to Brain Tissue.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Acute Neuropixels Recordings in the Marmoset Monkey.eNeuro · 2024Article
- Pre-saccadic Neural Enhancements in Marmoset Area MT.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multi-area recordings and optogenetics in the awake, behaving marmoset.Nature communications · 2023Article
- Acclimatizing and training freely viewing marmosets for behavioral and electrophysiological experiments in oculomotor tasks.Physiological reports · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Retinorecipient areas in the common marmoset (Frontiers in neural circuits · 2023Review
- Brain states in freely behaving marmosets.Sleep · 2022Article
- Review
- Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys.Nature communications · 2022Article
- Marmosets: a promising model for probing the neural mechanisms underlying complex visual networks such as the frontal-parietal network.Brain structure & function · 2021Review
- Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation.Nature communications · 2021Article
- An Open Resource for Non-human Primate Optogenetics.Neuron · 2020Article
- Histological assessment of optogenetic tools to study fronto-visual and fronto-parietal cortical networks in the rhesus macaque.Scientific reports · 2020Article
- Spinal cord neural interfacing in common marmosets (Callithrix jacchus).Journal of neural engineering · 2020Article
- Behavioral training of marmosets and electrophysiological recording from the cerebellum.Journal of neurophysiology · 2019Article
- Toward the Optical Cochlear Implant.Cold Spring Harbor perspectives in medicine · 2019Review
- Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective.Theranostics · 2019Review
- Comparative Principles for Next-Generation Neuroscience.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Optogenetics has revolutionized the study of functional neuronal circuitry (Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Nat Neurosci 8: 1263-1268, 2005; Deisseroth K. Nat Methods 8: 26-29, 2011). Although these techniques have been most successfully implemented in rodent models, they have the potential to be similarly impactful in studies of nonhuman primate brains. Common marmosets (Callithrix jacchus) have recently emerged as a candidate primate model for gene editing, providing a potentially powerful model for studies of neural circuitry and disease in primates. The application of viral transduction methods in marmosets for identifying and manipulating neuronal circuitry is a crucial step in developing this species for neuroscience research. In the present study we developed a novel, chronic method to successfully induce rapid photostimulation in individual cortical neurons transduced by adeno-associated virus to express channelrhodopsin (ChR2) in awake marmosets. We found that large proportions of neurons could be effectively photoactivated following viral transduction and that this procedure could be repeated for several months. These data suggest that techniques for viral transduction and optical manipulation of neuronal populations are suitable for marmosets and can be combined with existing behavioral preparations in the species to elucidate the functional neural circuitry underlying perceptual and cognitive processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.