ReviewCritical care (London, England)2016
Volumetric capnography: lessons from the past and current clinical applications.
Review in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03218943 (Physiological Dead Space Measured by Volumetric Capnography, Is it Different Between the Biphasic Positive Airway Pressure Mode), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological Dead Space Measured by Volumetric Capnography, Is it Different Between the Biphasic Positive Airway Pressure Mode ( BiPAP ) and Airway Pressure Release Ventilation Mode ( APRV ) ? A Randomized Controlled Study.
Who cites it
45 citing papers in PubMed, 110 citations in OpenAlex.
- Neurally adjusted ventilatory assist vs pressure support ventilation: short-term effects on shunt and dead space after cardiac surgery.Scientific reports · 2025Trial
- The effect of long-acting dual bronchodilator therapy on exercise tolerance, dynamic hyperinflation, and dead space during constant work rate exercise in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Low end-tidal carbon dioxide identifies high-severity pulmonary embolism and shock-level haemodynamics.ERJ open research · 2026Article
- Elevated carbon dioxide in exhaled breath induces false-positive DOB results during Helicobacter pylori detection with ¹³C-urea breath test using infrared spectroscopy.BMC gastroenterology · 2026Article
- Physiological dissociation between ventilatory ratio and ventilatory efficiency in patients with ARDS.Intensive care medicine experimental · 2026Article
- Continuous carbon dioxide monitoring in the exhaled breath of mechanically ventilated rats.Experimental physiology · 2026Article
- Dead space in critical care: a practical approach with clinical scenarios.Journal of anesthesia, analgesia and critical care · 2026Review
- Pioneers and Pathfinders: 10 years of Frontiers in Medicine from t(ether)ed in-person medicine to untethered telemedicine.Frontiers in medicine · 2026Article
- Pulmonary embolism consensus.Archivos de cardiologia de Mexico · 2026Article
- Noncontact Visualization of Respiration and Vital Sign Monitoring Using a Single Mid-Wave Infrared Thermal Camera: Preliminary Proof-of-Concept.Sensors (Basel, Switzerland) · 2025Article
- Time-Based Capnography to Diagnose Airway Obstruction During Lung Lobectomy in a Dog.Animals : an open access journal from MDPI · 2025Article
- Effects of inhaled bronchodilators on dynamic lung mechanics during exercise in COPD: protocol for a randomised, placebo-controlled crossover trial.ERJ open research · 2025Article
- High PEEP Increases Airway Dead Space and Decreases Alveolar Ventilation: A New Technique for Volumetric Capnography.Biomedicines · 2025Article
- Wasted ventilation in mild COPD: protocol for a clinical physiology and functional imaging study.ERJ open research · 2025Article
- Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome.Annals of intensive care · 2025Article
- Validation of a method for estimating pulmonary dead space in ventilated beagles to correct exhaled propofol concentration in mixed air.BMC veterinary research · 2025Article
- Development and preliminary tests of a portable volumetric capnograph for outpatient use.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- Accelerating the Diagnosis of Pandemic Infection Based on Rapid Sampling Algorithm for Fast-Response Breath Gas Analyzers.Sensors (Basel, Switzerland) · 2024Article
- Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome.Journal of intensive medicine · 2024Article
- Lung ultrasound is associated with distinct clinical phenotypes in COVID-19 ARDS: A retrospective observational study.PloS one · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dead space is an important component of ventilation-perfusion abnormalities. Measurement of dead space has diagnostic, prognostic and therapeutic applications. In the intensive care unit (ICU) dead space measurement can be used to guide therapy for patients with acute respiratory distress syndrome (ARDS); in the emergency department it can guide thrombolytic therapy for pulmonary embolism; in peri-operative patients it can indicate the success of recruitment maneuvers. A newly available technique called volumetric capnography (Vcap) allows measurement of physiological and alveolar dead space on a regular basis at the bedside. We discuss the components of dead space, explain important differences between the Bohr and Enghoff approaches, discuss the clinical significance of arterial to end-tidal CO2 gradient and finally summarize potential clinical indications for Vcap measurements in the emergency room, operating room and ICU.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.