Evidence map›Paper›PMID 27334789›Full record

ReviewProgress in biophysics and molecular biology2016

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.

Hermenegild J Arevalo, Patrick M Boyle, Natalia A Trayanova

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in biophysics and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Cardiac ischemia-insights from computational models.Herzschrittmachertherapie & Elektrophysiologie · 2018
    Review
  5. Effect of ventricular myocardium characteristics on the defibrillation threshold.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Hermenegild J ArevaloDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Simula Research Laboratory, Oslo, Norway.
Patrick M BoyleDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Natalia A TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: ntrayanova@jhu.edu.
Johns Hopkins University · US

Funding

Virtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS R01 HL126802
6 · The paper itself

Abstract

Current understanding of cardiac electrophysiology has been greatly aided by computational work performed using rabbit ventricular models. This article reviews the contributions of multiscale models of rabbit ventricles in understanding cardiac arrhythmia mechanisms. This review will provide an overview of multiscale modeling of the rabbit ventricles. It will then highlight works that provide insights into the role of the conduction system, complex geometric structures, and heterogeneous cellular electrophysiology in diseased and healthy rabbit hearts to the initiation and maintenance of ventricular arrhythmia. Finally, it will provide an overview on the contributions of rabbit ventricular modeling on understanding the mechanisms underlying shock-induced defibrillation.

Indexed as

Models, CardiovascularAnimalsArrhythmias, CardiacElectric CountershockElectrophysiological PhenomenaHeart VentriclesHumansRabbitsVoltage-Sensitive Dye ImagingCardiac electrophysiologyComputational modelingDefibrillationIschemiaMyocardial infarctionVentricular arrhythmia

Identifiers

PMID27334789
PMCPMC4947552
OpenAlexW2470117424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.