ArticleAllergy, asthma & immunology research2016
Short-, Intermediate-, and Long-Term Changes in Basophil Reactivity Induced by Venom Immunotherapy.
Article in Allergy, asthma & immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Pilot Randomised Controlled Dose-Ranging Trial of Ant Venom Immunotherapy With and Without Delta-Inulin Adjuvant.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Trial
- IgE levels correlate with FcFrontiers in allergy · 2026Article
- The usefulness of the basophil activation test for monitoring the effectiveness of wasp venom immunotherapy in different age groups.Clinical and translational allergy · 2025Article
- Article
- Basophil activation test in Hymenoptera venom allergy.Allergologie select · 2024Review
- Article
- Review
- Association between Venom Immunotherapy and Changes in Serum Protein-Peptide Patterns.Vaccines · 2021Article
- Basophil Activation as Marker of Clinically Relevant Allergy and Therapy Outcome.Frontiers in immunology · 2020Review
- Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis.Asia Pacific allergy · 2018Article
- Allergen-specific immunotherapy of Hymenoptera venom allergy - also a matter of diagnosis.Human vaccines & immunotherapeutics · 2017Review
- A Case of Immediate Hypersensitivity Reaction to Maltitol.Case reports in medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant decrease in basophil activation during 5 years of VIT and clinical protection assessed by sting challenge. The following prospective study was performed to examine changes in basophil reactivity over a complete VIT period of 5 years.
methodsBAT in a dose-response curve was studied prospectively in 10 hymenoptera venom-allergic patients over 5 years of VIT. BAT was performed at the time of diagnosis, 1 month after finishing the VIT build-up phase, and 3, 6, 12, 24, and 60 months after beginning treatment. The repeated measures ANOVA was applied to evaluate basophil activation changes throughout VIT. A cross-sectional study was also performed in 6 patients who received treatment for more than 3 years, and in another 12 patients who followed immunotherapy for at least 5 years.
resultsAn early activation decrease was observed during the first 3 months of treatment, compared to pre-treatment values. This activation decrease was not maintained 6 to 18 months after treatment, but was observed again after 2 years of treatment, and maintained until the completion of the 5-year immunotherapy period. In cross-sectional analysis, the 6 patients who received treatment for 3 years, and 9 of the 12 patients who received treatment for 5 years, had negative BAT results. Three patients in this last group had positive BAT results and 2 patients had systemic reactions after field stings.
conclusionsBAT appears to be an optimal non-invasive test for close monitoring of VIT.
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