Evidence map›Paper›PMID 27334778›Full record

ArticleAllergy, asthma & immunology research2016

Does Spore Count Matter in Fungal Allergy?: The Role of Allergenic Fungal Species.

Wan Rou Lin, Yi Hsing Chen, Mey Fann Lee, Ling Yi Hsu, Chih Jen Tien, Feng Ming Shih, Shih Ching Hsiao, Pi Han Wang

Open access · hybridAbstract read
In one paragraph

Article in Allergy, asthma & immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. Plant MicrofungiInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. MicrofungusCells · 2025
    Article
  4. In vitro Study of Fungus-Like OrganismsJournal of inflammation research · 2025
    Article
  5. The Potential Proallergenic Activity ofJournal of inflammation research · 2025
    Article
  6. Impact of Fungal Spores on Asthma Prevalence and Hospitalization.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Comprehensive Fungal Community Analysis of House Dust Using Next-Generation Sequencing.International journal of environmental research and public health · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Does Specific Fungal Allergen Really Matter?Allergy, asthma & immunology research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wan Rou LinDepartment of Life Science, Tunghai University, Taichung, Taiwan.
Yi Hsing ChenDivision of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan. ysanne@vghtc.gov.tw.
Mey Fann LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Ling Yi HsuThe Environmental Analysis Laboratory, Taoyuan, Taiwan.
Chih Jen TienDepartment of Life Science, Tunghai University, Taichung, Taiwan.
Feng Ming ShihDepartment of Life Science, Tunghai University, Taichung, Taiwan.
Shih Ching HsiaoDepartment of Life Science, Tunghai University, Taichung, Taiwan.
Pi Han WangDepartment of Life Science, Tunghai University, Taichung, Taiwan. phwang@thu.edu.tw.
Tunghai University · TWEnvironmental Protection Administration · TWNational Yang Ming Chiao Tung University · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFungi have been known to be important aeroallergens for hundreds of years. Most studies have focused on total fungal concentration; however, the concentration of specific allergenic fungi may be more important on an individual basis.

methodsTen fungal allergic patients and 2 non-fungal allergic patients were enrolled. The patients with a decrease in physician or patient global assessment by more than 50% of their personal best were considered to have an exacerbation of allergic symptoms and to be in the active stage. Those who maintained their physician and patient global assessment scores at their personal best for more than 3 months were considered to be in the inactive stage. The concentrations of dominant fungi in the patients' houses and outdoors were measured by direct and viable counts at active and inactive stages.

resultsThe exacerbation of allergic symptoms was not correlated with total fungal spore concentration or the indoor/outdoor ratio (I/O). Specific fungi, such as Cladosporium oxysporum (C. oxyspurum), C. cladosporioides, and Aspergillus niger (A. niger), were found to be significantly higher concentrations in the active stage than in the inactive stage. Presumed allergenic spore concentration threshold levels were 100 CFU/m³ for C. oxysporum, and 10 CFU/m³ for A. niger, Penicillium brevicompactum and Penicillium oxalicum.

conclusionsThe major factor causing exacerbation of allergic symptoms in established fungal allergic patients may be the spore concentration of specific allergenic fungi rather than the total fungal concentration. These results may be useful in making recommendations as regards environmental control for fungal allergic patients.

Indexed as

airborne fungal sporeFungal allergyhouseholdI/O ratiospore countthreshold level

Identifiers

PMID27334778
PMCPMC4921694
OpenAlexW2422664769

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.