ArticleInternational journal of stroke : official journal of the International Stroke Society2016
Early neurological stability predicts adverse outcome after acute ischemic stroke.
Article in International journal of stroke : official journal of the International Stroke Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Low-Molecular-Weight Heparin Versus Aspirin in Early Management of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Efficacy of immediate anti-hypertensive treatment in patients with acute ischaemic stroke stratified by mean arterial pressure and pulse pressure: a secondary analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.Stroke and vascular neurology · 2025Trial
- Early neurological improvement with deferoxamine after intracerebral hemorrhage: A post hoc analysis of the i-DEF trial.International journal of stroke : official journal of the International Stroke Society · 2025Trial
- Early Neurological Deterioration following acute stroke: association with reperfusion therapies and National Institutes Of Health Stroke Scale score.Frontiers in stroke · 2025Article
- Predictors of favorable functional outcomes for elderly patients undergoing endovascular thrombectomy for acute ischemic stroke.European journal of medical research · 2024Observational
- Association of pre-mechanical thrombectomy collateral scores with functional outcomes in the early versus extended window for thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- Establishing a hyperacute stroke service during the COVID-19 pandemic: our institution's one year experience.BMC neurology · 2023Article
- Location-weighted versus Volume-weighted Mismatch at MRI for Response to Mechanical Thrombectomy in Acute Stroke.Radiology · 2023Observational
- Outcome predictors in anterior and posterior ischemic strokes: a study based on the Iranian SITS registry.Scientific reports · 2023Article
- Predicting Functional Outcome Using 24-Hour Post-Treatment Characteristics: Application of Machine Learning Algorithms in the STRATIS Registry.Annals of neurology · 2023Article
- Relationship Between Body Temperature and Early Neurological Deterioration after Endovascular Thrombectomy for Acute Ischemic Stroke with Large Vessel Occlusion.Neurocritical care · 2022Article
- Association of the 24-Hour National Institutes of Health Stroke Scale After Mechanical Thrombectomy With Early and Long-Term Survival.Stroke (Hoboken, N.J.) · 2022Article
- Review
- Temporal trends in reperfusion therapy for patients with acute ischemic stroke.Journal of the American College of Emergency Physicians open · 2022Article
- Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers.Neuropsychiatric disease and treatment · 2022Article
- Observational
- Article
- Diagnosis of Early Neurological Deterioration after Intravenous Thrombolysis for Patients with Cerebral Ischemic Stroke Using Compressed Sensing-Magnetic Resonance Imaging Algorithm.Contrast media & molecular imaging · 2021Article
- Automated quantitative assessment of cerebral edema after ischemic stroke using CSF volumetrics.Neuroscience letters · 2020Review
- Effect of Conscious Sedation vs. General Anesthesia on Outcomes in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke: A Prospective Randomized Clinical Trial.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Background Deterioration in the National Institutes of Health Stroke Scale (NIHSS) in the early days after stroke is associated with progressive infarction, brain edema, and/or hemorrhage, leading to worse outcome. Aims We sought to determine whether a stable NIHSS score represents an adverse or favorable course. Methods Brain magnetic resonance images from a research cohort of acute ischemic stroke patients were analyzed. Using NIHSS scores at baseline and follow-up (day 3-5), patients were categorized into early neurological deterioration (ΔNIHSS ≥ 4), early neurological recovery (ΔNIHSS ≤ -4) or early neurological stability (ΔNIHSS between -3 and 3). The association between these categories and volume of infarct growth, volume of swelling, parenchymal hemorrhage, and 3-month modified Rankin Scale score were evaluated. Results Patients with early neurological deterioration or early neurological stability were less likely to be independent (modified Rankin Scale = 0-2) at 3 months compared to those with early neurological recovery ( P < 0.001). Patients with early neurological deterioration or early neurological stability were observed to have significantly greater infarct growth and swelling volumes than those with early neurological recovery ( P = 0.03; P < 0.001, respectively). Brain edema was more common than the other imaging markers investigated and was independently associated with a stable or worsening NIHSS score after adjustment for age, baseline stroke volume, infarct growth volume, presence of parenchymal hemorrhage, and reperfusion ( P < 0.0001). Conclusions Stable NIHSS score in the subacute period after ischemic stroke may not be benign and is associated with tissue injury, including infarct growth and brain edema. Early improvement is considerably more likely to occur in the absence of these factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.