ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Influence of the central-to-peripheral arterial stiffness gradient on the timing and amplitude of wave reflections.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Trial
- Effects of Exercise on Arterial Stiffness: Mechanistic Insights into Peripheral, Central, and Systemic Vascular Health in Young Men.Metabolites · 2025Review
- Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta : The Obstructive Descending Aorta in HLHS.Journal of cardiovascular translational research · 2022Article
- Vascular aging in adult congenital heart disease-a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- Higher carotid-radial pulse wave velocity is associated with non-melancholic depressive symptoms in men - findings from Helsinki Birth Cohort Study.Annals of medicine · 2021Article
- Isolated systolic hypertension in young males: a scoping review.Clinical hypertension · 2021Article
- Relationship between fiducial points on the peripheral and central blood pressure waveforms: rate of rise of the central waveform is a determinant of peripheral systolic blood pressure.American journal of physiology. Heart and circulatory physiology · 2021Article
- Investigation of Aortic Wall Thickness, Stiffness and Flow Reversal in Patients With Cryptogenic Stroke: A 4D Flow MRI Study.Journal of magnetic resonance imaging : JMRI · 2021Article
- Central Pressure Waveform-Derived Indexes Obtained From Carotid and Radial Tonometry and Brachial Oscillometry in Healthy Subjects (2-84 Y): Age-, Height-, and Sex-Related Profiles and Analysis of Indexes Agreement.Frontiers in physiology · 2021Article
- Influence of sprint exercise on aortic pulse wave velocity and femoral artery shear patterns.European journal of applied physiology · 2020Article
- Backward in Coming Forward.American journal of hypertension · 2019Article
- 'Compliance' to exercise: how much is really needed for a healthy heart (and mind)?The Journal of physiology · 2018Article
- Central hemodynamics and left ventricular hypertrophy in chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Effects of exercise intensity and cardiorespiratory fitness on the acute response of arterial stiffness to exercise in older adults.European journal of applied physiology · 2018Article
- Reliability of pulse waveform separation analysis responses to an orthostatic challenge.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Ejection time: influence of hemodynamics and site of measurement in the arterial tree.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Observational
- Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs.Advanced healthcare materials · 2017Article
- What is important for aging-induced arterial stiffening, autonomic dysfunction, vascular characteristics or both?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- The time is ripe to reevaluate the second derivative of the digital photoplethysmogram (SDPTG), originating in Japan, as an important tool for cardiovascular risk and central hemodynamic assessment.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In individuals with compliant aortas, peripheral muscular artery stiffness exceeds central elastic artery stiffness. With aging, central stiffness increases with little change in peripheral stiffness, resulting in a reversal of the normal stiffness gradient. This reversal may reduce the wave reflection amplitude due to the movement of the major 'effective' reflection site further from the heart. To test this phenomenon, we investigated the relationship among arterial stiffness gradients (normal and reversed), wave reflection amplitude and reflection site distance. Subjects aged ⩾50 years were recruited from the Anglo-Cardiff Collaborative Trial. Central stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). In Study 1, peripheral PWV was also measured in the arm (carotid-radial pulse wave velocity) and, in Study 2, in the leg (femoral-dorsalis pedis). Reflection site distance was calculated from cfPWV and the reflected wave Tr. Subjects were dichotomized into those with a normal stiffness gradient (peripheral >central PWV) or a reversed gradient (peripheral <central PWV). In Study 1, the reflection site distance was greater in subjects with a reversed gradient (P<0.01), whereas time-to-reflection was lower (P<0.001). Both the augmentation pressure (P<0.001) and augmentation index (P<0.05) were greater in subjects with a reversed gradient. In Study 2, the augmentation pressure, augmentation index and reflection site distance were greater in subjects with a reversed stiffness gradient (P<0.01, P<0.05 and P<0.01, respectively), and time-to-reflection was not different between groups. A reversed arterial stiffness gradient is associated with an increased reflection site distance, and a paradoxical increase in reflected wave amplitude and augmentation index.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.