Evidence map›Paper›PMID 27334059›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2016

Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice.

Hirofumi Zempo, Jun-Ichi Suzuki, Masahito Ogawa, Ryo Watanabe, Katsuhito Fujiu, Ichiro Manabe, Simon J Conway, Yoshiaki Taniyama, Ryuichi Morishita, Yasunobu Hirata and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Genetic variants and mRNA expression levels ofJournal of biomedical research · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Krüppel-like factors and vascular wall homeostasis.Journal of molecular cell biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Hirofumi ZempoDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Jun-Ichi SuzukiDepartment of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan.
Masahito OgawaWestmead Millennium Institute for Medical Research, Westmead, New South Wales, Australia.
Ryo WatanabeDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Katsuhito FujiuDepartment of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan.
Ichiro ManabeDepartment of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan.
Simon J ConwayDevelopmental Biology and Neonatal Medicine Program, Herman B Wells Center for Pediatric Research, Indiana University of Medicine, Indianapolis, IN, USA.
Yoshiaki TaniyamaDepartment of Clinical Gene Therapy, Osaka University, Osaka, Japan.
Ryuichi MorishitaDepartment of Clinical Gene Therapy, Osaka University, Osaka, Japan.
Yasunobu HirataDepartment of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan.
Mitsuaki IsobeDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Ryozo NagaiJichi Medical University, Shimotsuke City, Tochigi, Japan.
The University of Tokyo · JPTokyo Medical and Dental University · JPOsaka University · JPIndiana University – Purdue University Indianapolis · USJichi Medical University · JPWestmead Institute for Medical Research · AU

Funding

Role of TGFbeta superfamily in Broncopulmonary DysplasiaR01HL115619 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CONWAY, SIMON JAMES · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL115619
6 · The paper itself

Abstract

Chronic hypertension causes vascular remodeling that is associated with an increase in periostin- (postn) positive cells, including fibroblasts and smooth muscle cells. Krüppel-like factor (KLF) 5, a transcription factor, is also observed in vascular remodeling; however, it is unknown what role KLF5 plays in postn-positive cells during vascular remodeling induced by deoxycorticosterone-acetate (DOCA) salt. We used postn-positive cell-specific Klf5-deficient mice (Klf5

Indexed as

AnimalsAortaBlood PressureCell Adhesion MoleculesDesoxycorticosterone AcetateHypertensionKruppel-Like Transcription FactorsMiceMice, KnockoutMyofibroblastsS100 Calcium-Binding Protein A4Vascular RemodelingCell Adhesion MoleculesDesoxycorticosterone AcetateKlf5 protein, mouseKruppel-Like Transcription FactorsPostn protein, mouseS100a4 protein, mouseS100 Calcium-Binding Protein A4

Identifiers

PMID27334059
PMCPMC5583721
OpenAlexW2467889112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.