Evidence map›Paper›PMID 27333913›Full record

Trial reportEuropean journal of applied physiology2016

Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men.

Adam M Gonzalez, Jay R Hoffman, Jeremy R Townsend, Adam R Jajtner, Carleigh H Boone, Kyle S Beyer, Kayla M Baker, Adam J Wells, Gerald T Mangine, Edward H Robinson and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?International journal of environmental research and public health · 2020
    Review
  5. The Effect of ProHydrolaseSports (Basel, Switzerland) · 2020
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Adam M GonzalezDepartment of Health Professions, Hofstra University, Hempstead, NY, USA.
Jay R HoffmanInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA. Jay.Hoffman@ucf.edu.
Jeremy R TownsendInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Adam R JajtnerInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Carleigh H BooneInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Kyle S BeyerInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Kayla M BakerInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Adam J WellsInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Gerald T MangineInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Edward H RobinsonInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
David D ChurchInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Leonardo P OliveiraInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
David H FukudaInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Jeffrey R StoutInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
University of Central Florida · USHofstra University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the mitogen-activated protein kinase (MAPK) family of signaling proteins following typical high volume (HV) and high intensity (HI) lower body resistance exercise protocols in resistance-trained men.

methodsTen resistance-trained men (24.7 ± 3.4 year; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) performed each resistance exercise protocol in a random, counterbalanced order. The HV protocol utilized a load of 70 % 1-RM for sets of 10-12 repetitions with a 1-min rest period length between sets and exercises. The HI protocol utilized a load of 90 % 1-RM for sets of 3-5 repetitions with a 3-min rest period length between sets and exercises. Both protocols included six sets of barbell back squats and four sets of bilateral leg press, bilateral hamstring curls, bilateral leg extensions, and seated calf raises. Fine needle muscle biopsies of the vastus lateralis were completed at baseline (BL) and 1-h post exercise (1H).

resultsNo significant differences over time were noted for phosphorylation of MEK1, ERK1/2, p38, MSK1, ATF2, p53, or c-Jun (p > 0.05). No significance between trial interactions was noted for phosphorylation of MAPK signaling proteins, including MEK1, ERK1/2, p38, JNK, MSK1, ATF2, STAT1, p53, c-Jun, or HSP27 (p > 0.05). However, significant time effects were observed for phosphorylation of JNK (p < 0.01), HSP27 (p < 0.01), and STAT1 (p = 0.03). Phosphorylation of JNK, HSP27, and STAT1 was significantly elevated from BL at 1H for both HV and HI.

conclusionsHV and HI lower body resistance exercise protocols appear to elicit similar MAPK activation in resistance-trained men.

Indexed as

ExerciseHigh-Intensity Interval TrainingHumansLegMaleMAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesMuscle, SkeletalPhysical Conditioning, HumanPhysical ExertionPhysical FitnessResistance TrainingYoung AdultMitogen-Activated Protein Kinase KinasesAnabolic intramuscular signalingERKJNKMitogen-activated protein kinasep38

Identifiers

PMID27333913
OpenAlexW2472475562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.