ArticleMedical science monitor : international medical journal of experimental and clinical research2016
Astaxanthin Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest of Mice H22 Hepatoma Cells.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats.Scientific reports · 2025Article
- The Anticancer Effect of Haematococcus Pluvialis Alga Extract on Breast Cancer Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Astaxanthin supplementation mitigated intestinal damage and immunity in overfed Pekin ducks by regulating gut morphology, intestinal inflammation, and antioxidant balance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Astaxanthin in cancer therapy and prevention (Review).Biomedical reports · 2025Review
- Astaxanthin-Based Biomaterials for Tissue Repair and Drug Delivery Systems.Biomaterials research · 2025Review
- Carotenoids from Different Pumpkin Varieties Exert a Cytotoxic Effect on Human Neuroblastoma SH-SY5Y Cells.Nutrients · 2024Article
- Astaxanthin Alleviates Autoimmune Hepatitis by Modulating CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential.Molecules (Basel, Switzerland) · 2022Review
- Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders.Food science & nutrition · 2022Review
- [Therapeutic mechanism of natural astaxanthin against renal clear cell carcinoma based on network pharmacology and bioinformatics].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids.Marine drugs · 2021Review
- Carotenoids in Cancer Apoptosis-The RoadCancers · 2020Review
- Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent.Drug design, development and therapy · 2020Review
- Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells.In vitro cellular & developmental biology. Animal · 2019Article
- Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity.Molecules (Basel, Switzerland) · 2018Article
- Total Flavonoids fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND It is widely recognized that astaxanthin (ASX), a member of the carotenoid family, has strong biological activities including antioxidant, anti-inflammation, and immune-modulation activities. Previous studies have confirmed that ASX can effectively inhibit hepatoma cells in vitro. MATERIAL AND METHODS MTT was used to assay proliferation of mice H22 cells, and flow cytometry was used to determine apoptosis and cell cycle arrest of H22 cells in vitro and in vivo. Moreover, anti-tumor activity of ASX was observed in mice. RESULTS ASX inhibited the proliferation of H22 cells, promoted cell necrosis, and induced cell cycle arrest in G2 phase in vitro and in vivo. CONCLUSIONS This study indicated that ASX can inhibit proliferation and induce apoptosis and cell cycle arrest in mice H22 hepatoma cells in vitro and in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.