Evidence map›Paper›PMID 27333829›Full record

ArticleClinical oral implants research2017

Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses.

Simon Meyer, Catherine Giannopoulou, Delphine Courvoisier, Martin Schimmel, Frauke Müller, Andrea Mombelli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral implants research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
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  4. Trial
  5. [Treatment of peri-implant mucositis using an erythritol air-polishing or ultrasonic device: A randomized controlled trial].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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  11. Peri-Implant Diseases: The Past, the Present, the Future.Journal of periodontal research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Simon MeyerSchool of Dental Medicine, University of Geneva, Geneva, Switzerland.
Catherine GiannopoulouSchool of Dental Medicine, University of Geneva, Geneva, Switzerland.
Delphine CourvoisierDivision of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.
Martin SchimmelSchool of Dental Medicine, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-9700-5534
Frauke MüllerSchool of Dental Medicine, University of Geneva, Geneva, Switzerland.
Andrea MombelliSchool of Dental Medicine, University of Geneva, Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Geneva · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare in persons aged 70 years or older the clinical and inflammatory changes occurring around implants and natural teeth during and after a phase of undisturbed plaque accumulation. MATERIAL AND

methodsTwenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored for 3 weeks. Twelve biomarkers were assessed in gingival and peri-implant crevicular fluid (GCF, PCF).

resultsDuring 3 weeks of oral hygiene abstention, the gingival index (GI) continuously increased. On day 21, there were significantly more sites with GI >1 at implants than at teeth. After restarting oral hygiene, the GI decreased markedly in both groups. Throughout the experiment, the plaque index was significantly higher on teeth than on implants. The different biomarkers reacted variably. IL-1β increased significantly with plaque accumulation. IL-1β, GM-CSF, TNF-α, and IFN-γ were significantly higher in GCF compared to PCF at day 21. IL-8 decreased significantly in GCF up to day 14. MIP-1β decreased significantly in GCF, but not in PCF. At the 3-week follow-up, the levels of all biomarkers assessed in GCF and PCF had returned to baseline values.

conclusionsIn an elderly cohort, plaque accumulation induced an inflammatory reaction around both teeth and implants. Although there was less plaque accumulation on implants, the peri-implant mucosa showed a stronger clinical response than gingiva.

Indexed as

AgedAged, 80 and overBiomarkersChemokine CCL4Dental ImplantsDental PlaqueFemaleGingival Crevicular FluidGingivitisGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-1betaInterleukin-8MalePeriodontal IndexStomatitisBiomarkersChemokine CCL4Dental ImplantsGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-1betaInterleukin-8Tumor Necrosis Factor-alphaadultagedbiomarkersdental implantsgingival crevicular fluidgingivitismucositisoral hygiene

Identifiers

PMID27333829
PMCPMC5599942
OpenAlexW2464450000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.