ArticleScientific reports2016
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.
Registry-linked trialAbstract read
In one paragraph
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05419336 (Child Growth and Development in East London), which is not on this map. Cited by 90 papers.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Child Growth and Development in East London
Who cites it
90 citing papers in PubMed.
- The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- Design and model choices shape inference of age-varying genetic effects on complex traits.Nature aging · 2026Article
- Developing Growth Reference Curves for Jordanian Children and Adolescents: A Comparative Analysis with WHO Growth Standards and References.Healthcare (Basel, Switzerland) · 2026Article
- Association of infrarenal aortic diameter in siblings within the Stockholm abdominal aortic aneurysm screening programme.The British journal of surgery · 2026Article
- A maternal effect shapes early-life adaptive body size variation in house mice.bioRxiv : the preprint server for biology · 2026Article
- Chronic Intestinal Failure During the Neonatal Period Related to Height at Five Years of Age.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.HGG advances · 2026Article
- Secular Trend and Socioeconomic Variation in Body Height of Young Polish Men Between 1965 and 2023.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Gestational exposure to organophosphate ester flame retardants and child growth in weight, height, and body mass index at age 2-10 years: the Environmental influences on Child Health Outcomes Program.Environmental research · 2026Article
- FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets.PLoS genetics · 2026Article
- Genetic regulation of body size and morphology from adolescence to early adulthood.Pediatric research · 2026Article
- Blood-based DNA methylation captures variance in adult height.Genome biology · 2026Article
- Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature.American journal of human genetics · 2026Article
- Final height prediction of girls at menarche: a combined model using left hand and wrist bone age, knee radiomic scores, and clinical characteristics.World journal of pediatrics : WJP · 2026Article
- Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits.Human molecular genetics · 2025Article
- Genetic and Environmental Contributions to Child Height in Low- and Middle-Income Countries.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- BIGFAM - variance components analysis from relatives without genotype.Nature communications · 2025Article
- Theory of random measurement errors: concepts, uses, and misuses.Arhiv za higijenu rada i toksikologiju · 2025Review
- Addressing Stunting in Children Under Five: Insights and Opportunities from Nepal, Bangladesh, and Vietnam-A Review of Literature.Children (Basel, Switzerland) · 2025Review
- Socioeconomic Patterning of Stunting and Overweight Among Iranian Children Aged 2-5 Years: A National Cross-Sectional Analysis.Nutrients · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
103 authors.
Aline JelenkovicDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Reijo SundDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Yoon-Mi HurDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Yoshie YokoyamaDepartment of Public Health Nursing, Osaka City University, Osaka, Japan.
Jacob V B HjelmborgThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Sören MöllerThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Chika HondaOsaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Syuichi OokiDepartment of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan.
Sari AaltonenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Maria A StaziIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Corrado FagnaniIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Cristina D'IppolitoIstituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Duarte L FreitasDepartment of Physical Education and Sport, University of Madeira, Funchal, Portugal.
José Antonio MaiaCIFI2D, Faculty of Sport, Porto, University of Porto, Portugal.
Fuling JiDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Feng NingDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Zengchang PangDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Esther RebatoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Andreas BusjahnHealthTwiSt GmbH, Berlin, Germany.
Christian KandlerDepartment of Psychology, Bielefeld University, Bielefeld, Germany.
Kimberly J SaudinoBoston University, Department of Psychological and Brain Sciencies, Boston, MA, USA.
Kerry L JangDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Wendy CozenDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Amie E HwangDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Thomas M MackDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Wenjing GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Brooke M HuibregtseInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Catherine A DeromCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Robert F VlietinckCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kauko HeikkiläDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Jane WardleHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Clare H LlewellynHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Abigail FisherHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Tom A McAdamsKing's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Thalia C EleyKing's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Alice M GregoryDepartment of Psychology, Goldsmiths, University of London, London, UK.
Mingguang HeState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiaohu DingState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Morten Bjerregaard-AndersenBandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
Henning Beck-NielsenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Morten SodemannDepartment of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Adam D TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
David L TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
Ariel Knafo-NoamThe Hebrew University of Jerusalem, Jerusalem, Israel.
David MankutaHadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel.
Lior AbramsonThe Hebrew University of Jerusalem, Jerusalem, Israel.
S Alexandra BurtMichigan State University, East Lansing, Michigan, USA.
Kelly L KlumpMichigan State University, East Lansing, Michigan, USA.
Judy L SilbergDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Lindon J EavesDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Hermine H MaesDepartment of Human and Molecular Genetics, Psychiatry &Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Shandell PahlenDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Margaret GatzDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
David A ButlerInstitute of Medicine, National Academy of Sciences, Washington, DC, USA.
Meike BartelsDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Toos C E M van BeijsterveldtDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Jeffrey M CraigMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Richard SafferyMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Lise DuboisSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Michel BoivinÉcole de psychologie, Université Laval, Québec, Canada.
Mara BrendgenDépartement de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada.
Ginette DionneÉcole de psychologie, Université Laval, Québec, Canada.
Frank VitaroÉcole de psychoéducation, Université de Montréal, Montréal, Québec, Canada.
Nicholas G MartinGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sarah E MedlandGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Grant W MontgomeryMolecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Gary E SwanStanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Ruth KrasnowCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
Per TyneliusDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Claire M A HaworthMRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
Robert PlominKing's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Gombojav BayasgalanHealthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Danshiitsoodol NarandalaiGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Timothy SpectorDepartment of Twin Research and Genetic Epidemiology, King's College, London, UK.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College, London, UK.
Genevieve LachanceDepartment of Twin Research and Genetic Epidemiology, King's College, London, UK.
Laura A BakerDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Catherine TuvbladDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Glen E DuncanWashington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Dedra BuchwaldWashington State Twin Registry, Washington State University, Seattle, WA, USA.
Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Axel SkyttheThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Kirsten O KyvikDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Sevgi Y ÖncelDepartment of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Fazil AlievDepartments of Psychiatry, Psychology, and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA.
Finn RasmussenDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Jack H GoldbergDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Thorkild I A SørensenNovo Nordisk Foundation Centre for Basic Metabolic Research (Section on Metabolic Genetics) and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Karri SilventoinenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Funding
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MTRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5MRISK FACTORS FOR ANTISOCIAL BEHAVIORR01MH058354 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BAKER, LAURA A · 2000 to 2013
$8.5MBuilding a Unique National Community Based Twin RepositoryRC2HL103416 · NHLBI · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 2009 to 2010
$7.7MResearch Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3MScientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Elizabeth T. Gershoff · 2017 to 2026
$5.2MThe Effects of Estradiol on Genetic Risk for Disordered Eating During PubertyR01MH092377 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2010 to 2014
$3.4MA twin study of ovarian hormones and disordered eatingR01MH082054 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2008 to 2012
$3.1MDNA methylation differences between identical twinsR01ES015150 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, THOMAS MCCULLOCH · 2006 to 2009
$3.1MDETERMINANTS OF BEHAVIORAL DEVELOPMENT IN CHILDRENR01HD010333 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WADSWORTH, SALLY J · 1985 to 2010
$3.0MDevelopmental Change in Temperament in Preschoolers: Implications and EtiologyR01HD068435 · NICHD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SAUDINO, KIMBERLY J. · 2012 to 2016
$2.9MADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9MBiotechnology and Biological Sciences Research Council 31/D19086Cancer Research UK C1418/A7974European Research Council 230374Medical Research Council G120/635Medical Research Council G81/343NHLBI NIH HHS RC2 HL103416NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R21 AA023322NIAAA NIH HHS R37 AA012502NIA NIH HHS P01 AG008761NIA NIH HHS R21 AG039572NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD010333NICHD NIH HHS R01 HD066040NICHD NIH HHS R01 HD068435NICHD NIH HHS R21 HD081437NIDA NIH HHS P60 DA011015NIDA NIH HHS T32 DA017637NIEHS NIH HHS R01 ES015150NIMH NIH HHS R01 MH058354NIMH NIH HHS R01 MH062375NIMH NIH HHS R01 MH081813NIMH NIH HHS R01 MH082054NIMH NIH HHS R01 MH092377NIMH NIH HHS R03 MH063851NIMH NIH HHS R21 MH070542Wellcome Trust
Abstract
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
Indexed as
Body HeightEnvironmentAdolescentAsia, EasternAustraliaChildChild, PreschoolCohort StudiesEuropeFemaleGene-Environment InteractionGenetic VariationHumansInfantMaleNorth America
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Read underepoch 390
Registered trials
NCT05419336ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.