Evidence map›Paper›PMID 27333659›Full record

ReviewNihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology2016

Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR).

Domenico Tupone, Justin S Cetas, Shaun F Morrison

Abstract readReview
In one paragraph

Review in Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Precise Control of Target Temperature Using NTherapeutic hypothermia and temperature management · 2018
    Article
  7. Thermoregulatory inversion: a novel thermoregulatory paradigm.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Domenico Tupone
Justin S Cetas
Shaun F Morrison

Funding

Central Sympathetic Regulation of Thermogenesis in FeverR01NS040987 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2001 to 2013
$3.7M
Central inhibitory regulation of brown adipose thermogenesisR01NS091066 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2015 to 2018
$1.3M
Brainstem Control of Cerebral Blood Flow in Traumatic Subarachnoid HemorrhageI01BX001659 · VA · PORTLAND VA MEDICAL CENTER · PI CETAS, JUSTIN S. · 2014 to 2017
–
BLRD VA I01 BX001659NINDS NIH HHS R01 NS040987NINDS NIH HHS R01 NS091066
6 · The paper itself

Abstract

The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.

Indexed as

HomeostasisHypothermia, InducedAnimalsBody Temperature RegulationHumansReceptor, Adenosine A1StrokeSubarachnoid HemorrhageReceptor, Adenosine A1

Identifiers

PMID27333659
PMCPMC5005006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.