Evidence map›Paper›PMID 27333364›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2016

Interhemispheric Inhibition Measurement Reliability in Stroke: A Pilot Study.

Jessica M Cassidy, Haitao Chu, Mo Chen, Teresa J Kimberley, James R Carey

Abstract read
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In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica M CassidyDepartment of Physical Medicine and Rehabilitation, Programs in Physical Therapy and Rehabilitation Science, University of Minnesota, Minneapolis, MN, USA.
Haitao ChuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Mo ChenInstitute for Engineering in Medicine, University of Minnesota, Minneapolis, MN.
Teresa J KimberleyDepartment of Physical Medicine and Rehabilitation, Programs in Physical Therapy and Rehabilitation Science, University of Minnesota, Minneapolis, MN, USA.
James R CareyDepartment of Physical Medicine and Rehabilitation, Programs in Physical Therapy and Rehabilitation Science, University of Minnesota, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)UL1RR033183 · NCRR · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2011 to 2011
$8.9M
NCATS NIH HHS UL1 TR000114NCRR NIH HHS UL1 RR033183
6 · The paper itself

Abstract

objectiveReliable transcranial magnetic stimulation (TMS) measures for probing corticomotor excitability are important when assessing the physiological effects of noninvasive brain stimulation. The primary objective of this study was to examine test-retest reliability of an interhemispheric inhibition (IHI) index measurement in stroke. MATERIALS AND

methodsTen subjects with chronic stroke (≥6 months) completed two IHI testing sessions per week for three weeks (six testing sessions total). A single investigator measured IHI in the contra-to-ipsilesional primary motor cortex direction and in the opposite direction using bilateral paired-pulse TMS. Weekly sessions were separated by 24 hours with a 1-week washout period separating testing weeks. To determine if motor-evoked potential (MEP) quantification method affected measurement reliability, IHI indices computed from both MEP amplitude and area responses were found. Reliability was assessed with two-way, mixed intraclass correlation coefficients (ICC

resultsWith the exception of the initial testing week, IHI indices measured in the contra-to-ipsilesional hemisphere direction demonstrated moderate to excellent reliability (ICC = 0.725-0.913). Ipsi-to-contralesional IHI indices depicted poor or invalid reliability estimates throughout the three-week testing duration (ICC= -1.153-0.105). The overlap of ICC 95% confidence intervals suggested that IHI indices using MEP amplitude vs. area measures did not differ with respect to reliability.

conclusionsIHI indices demonstrated varying magnitudes of reliability irrespective of MEP quantification method. Several strategies for improving IHI index measurement reliability are discussed.

Indexed as

AgedAged, 80 and overAnalysis of VarianceEvoked Potentials, MotorFemaleFunctional LateralityHumansMaleMiddle AgedMotor CortexNeural InhibitionPilot ProjectsReproducibility of ResultsSeverity of Illness IndexStrokeTranscranial Magnetic StimulationInterhemispheric inhibitionmotor-evoked potentialreliabilitystrokestudy protocoltranscranial magnetic stimulation

Identifiers

PMID27333364
PMCPMC5138097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.