Evidence map›Paper›PMID 27333295›Full record

ReviewFuture oncology (London, England)2016

F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.

William H Gmeiner, Patricia J Gearhart, Yves Pommier, Jun Nakamura

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer.Physical chemistry chemical physics : PCCP · 2017
    Article
  10. MutSFrontiers in physics · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William H GmeinerDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Patricia J GearhartLaboratory of Molecular Biology & Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yves PommierDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
Jun NakamuraUniversity of North Carolina, Chapel Hill, NC 27599, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
STOCHASTIC ANALYSIS OF FLOW AND TRANSPORT PHENOMENAP42ES005948 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 1992 to 2017
$45.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer DrugsZIABC006150 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI POMMIER, YVES · 2009 to 2025
$23.0M
DNA Topoisomerases as Target of Action of Anticancer DrugsZIABC006161 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI POMMIER, YVES · 2009 to 2025
$16.8M
Roles for Transcription in Antibody DiversityZIAAG000714 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 2009 to 2025
$10.9M
NCI NIH HHS P30 CA012197NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES005948
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA RepairPolymersCell DeathDNA Breaks, Single-StrandedDNA Topoisomerases, Type IGene Knockdown TechniquesHumansPhosphoric Diester HydrolasesPyrimidinesThymineDNA Topoisomerases, Type IPhosphoric Diester HydrolasesPolymersPyrimidinesTDP1 protein, humanThymineDNA repairDNA topoisomerase IF10thymineless death

Identifiers

PMID27333295
PMCPMC5551924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.