ArticleBiophysical journal2016
Spatially Constrained Growth Enhances Conversional Meltdown.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape.Nature ecology & evolution · 2026Article
- Tunable low-rate genomic recombination with Cre-Applied and environmental microbiology · 2026Article
- Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations.PNAS nexus · 2025Article
- Graph-structured populations elucidate the role of deleterious mutations in long-term evolution.Nature communications · 2025Article
- Impact of crowding on the diversity of expanding populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.Nature communications · 2022Article
- Self-consistent dispersal puts tight constraints on the spatiotemporal organization of species-rich metacommunities.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Stochastic establishment of β-lactam-resistantProceedings. Biological sciences · 2022Article
- Article
- Article
- Emergence of evolutionary driving forces in pattern-forming microbial populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Article
- Allele surfing promotes microbial adaptation from standing variation.Ecology letters · 2016Article
- Watching Populations Melt Down.Biophysical journal · 2016Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
Cells that mutate or commit to a specialized function (differentiate) often undergo conversions that are effectively irreversible. Slowed growth of converted cells can act as a form of selection, balancing unidirectional conversion to maintain both cell types at a steady-state ratio. However, when one-way conversion is insufficiently counterbalanced by selection, the original cell type will ultimately be lost, often with negative impacts on the population's overall fitness. The critical balance between selection and conversion needed for preservation of unconverted cells and the steady-state ratio between cell types depends on the spatial circumstances under which cells proliferate. We present experimental data on a yeast strain engineered to undergo irreversible conversion: this synthetic system permits cell-type-specific fluorescent labeling and exogenous variation of the relative growth and conversion rates. We find that populations confined to grow on a flat agar surface are more susceptible than their well-mixed counterparts to fitness loss via a conversion-induced "meltdown." We then present analytical predictions for growth in several biologically relevant geometries-well-mixed liquid media, radially expanding two-dimensional colonies, and linear fronts in two dimensions-by employing analogies to the directed-percolation transition from nonequilibrium statistical physics. These simplified theories are consistent with the experimental results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.