ArticlePLoS neglected tropical diseases2016
The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pooled it
- A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.PLoS neglected tropical diseases · 2018Pooled it
- Seasonal dynamics of typhoid and paratyphoid fever.Scientific reports · 2018Pooled it
- Estimating enteric fever seroincidence in rural western Cambodia: Findings from a population-based cross-sectional serosurvey.PLoS neglected tropical diseases · 2026Article
- Estimating enteric fever seroincidence in rural western Cambodia: findings from a population-based cross-sectional serosurvey.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Flood-associated disease outbreaks and transmission in Southeast Asia.Frontiers in microbiology · 2025Review
- Review
- Burden of Typhoid and Paratyphoid Fever in India.The New England journal of medicine · 2023Article
- Article
- Changing Paradigms in Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Genomic epidemiology, antimicrobial resistance and virulence factors ofJAC-antimicrobial resistance · 2022Article
- Geographically Weighted Regression Modeling of Spatial Clustering and Determinants of Focal Typhoid Fever Incidence.The Journal of infectious diseases · 2021Article
- Genomic Epidemiology and Antimicrobial Resistance Mechanisms of Imported Typhoid in Australia.Antimicrobial agents and chemotherapy · 2021Article
- A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch.Nature communications · 2021Article
- Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Typhoid in Laos: An 18-Year Perspective.The American journal of tropical medicine and hygiene · 2020Article
- Status and potential of bacterial genomics for public health practice: a scoping review.Implementation science : IS · 2019Article
- Genomic analysis of Indian strains of Salmonella enterica subsp. enterica serovar Typhi indicates novel genetic repertoire for pathogenicity and adaptations.Molecular biology reports · 2019Article
- rPinecone: Define sub-lineages of a clonal expansion via a phylogenetic tree.Microbial genomics · 2019Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 5 countries.
Funding
Abstract
Typhoid fever, caused by the bacterium Salmonella Typhi, is an endemic cause of febrile disease in Cambodia. The aim of this study was to better understand the epidemiology of pediatric typhoid fever in Cambodia. We accessed routine blood culture data from Angkor Hospital for Children (AHC) in Siem Reap province between 2007 and 2014, and performed whole genome sequencing (WGS) on the isolated bacteria to characterize the S. Typhi population. The resulting phylogenetic information was combined with conventional epidemiological approaches to investigate the spatiotemporal distribution of S. Typhi and population-level risk factors for reported disease. During the study period, there were 262 cases of typhoid within a 100 km radius of AHC, with a median patient age of 8.2 years (IQR: 5.1-11.5 years). The majority of infections occurred during the rainy season, and commune incidences as high as 11.36/1,000 in children aged <15 years were observed over the study period. A population-based risk factor analysis found that access to water within households and increasing distance from Tonle Sap Lake were protective. Spatial mapping and WGS provided additional resolution for these findings, and confirmed that proximity to the lake was associated with discrete spatiotemporal disease clusters. We confirmed the dominance of MDR H58 S. Typhi in this population, and found substantial evidence of diversification (at least seven sublineages) within this single lineage. We conclude that there is a substantial burden of pediatric typhoid fever in rural communes in Cambodia. Our data provide a platform for additional population-based typhoid fever studies in this location, and suggest that this would be a suitable setting in which to introduce a school-based vaccination programme with Vi conjugate vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.