ArticleGenomics data2016
Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip.
Article in Genomics data, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers, 14 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
255 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- Post-traumatic stress disorder moderates the association between BrainAge acceleration and GrimAge acceleration.Neurobiology of aging · 2026Pooled it
- Schizophrenia is associated with altered DNA methylation variance.Molecular psychiatry · 2025Pooled it
- Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.Genome medicine · 2024Pooled it
- Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.Epigenetics · 2024Pooled it
- Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.Molecular psychiatry · 2023Pooled it
- Prenatal phthalate exposure and cord blood DNA methylation.Scientific reports · 2023Pooled it
- Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.European journal of nutrition · 2023Pooled it
- Disease classification for whole-blood DNA methylation: Meta-analysis, missing values imputation, and XAI.GigaScience · 2022Pooled it
- Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.Epigenetics · 2022Pooled it
- Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.Clinical epigenetics · 2022Pooled it
- Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci.Human molecular genetics · 2022Pooled it
- Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress.Molecular psychiatry · 2022Pooled it
- Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.Diabetologia · 2021Pooled it
- Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.Molecular psychiatry · 2021Pooled it
- DNA methylation GrimAge acceleration in US military veterans with PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome.Journal of translational medicine · 2022Trial
- DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.Aging cell · 2021Trial
- Article
- Protein epigenetic scores derived in neonatal saliva as biomarkers of childhood cognition.Molecular psychiatry · 2026Article
- Multi-omics identifies promoter methylation and gene expression changes associated with human skeletal muscle atrophy.Experimental physiology · 2026Article
195 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Genome-wide analysis of DNA methylation has now become a relatively inexpensive technique thanks to array-based methylation profiling technologies. The recently developed Illumina Infinium MethylationEPIC BeadChip interrogates methylation at over 850,000 sites across the human genome, covering 99% of RefSeq genes. This array supersedes the widely used Infinium HumanMethylation450 BeadChip, which has permitted insights into the relationship between DNA methylation and a wide range of conditions and traits. Previous research has identified issues with certain probes on both the HumanMethylation450 BeadChip and its predecessor, the Infinium HumanMethylation27 BeadChip, which were predicted to affect array performance. These issues concerned probe-binding specificity and the presence of polymorphisms at target sites. Using in silico methods, we have identified probes on the Infinium MethylationEPIC BeadChip that are predicted to (i) measure methylation at polymorphic sites and (ii) hybridise to multiple genomic regions. We intend these resources to be used for quality control procedures when analysing data derived from this platform.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.