Evidence map›Paper›PMID 27330969›Full record

ArticleNeuroImage. Clinical2016

Nucleus accumbens functional connectivity discriminates medication-overuse headache.

D M Torta, T Costa, E Luda, M G Barisone, P Palmisano, S Duca, G Geminiani, F Cauda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Medication-overuse headache: a narrative review.The journal of headache and pain · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives.Frontiers in pain research (Lausanne, Switzerland) · 2021
    Review
  12. Article
  13. Brain functional connectivity in headache disorders: A narrative review of MRI investigations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D M TortaGCS fMRI, Koelliker Hospital and University of Turin, Turin, Italy; Department of Psychology, University of Turin, Turin, Italy; Institute of Neuroscience, IoNS, Université catholique de Louvain, Brussels, Belgium. Electronic address: diana.torta@gmail.com.
T CostaGCS fMRI, Koelliker Hospital and University of Turin, Turin, Italy; Department of Psychology, University of Turin, Turin, Italy.
E LudaDivision of Neurology, Rivoli Hospital, Turin, Italy.
M G BarisoneDivision of Neurology, Rivoli Hospital, Turin, Italy; Neuropsychology Unit, Division of Neurology, Rivoli Hospital, Turin, Italy.
P PalmisanoDivision of Neurology, Rivoli Hospital, Turin, Italy; Neuropsychology Unit, Division of Neurology, Rivoli Hospital, Turin, Italy.
S DucaGCS fMRI, Koelliker Hospital and University of Turin, Turin, Italy.
G GeminianiGCS fMRI, Koelliker Hospital and University of Turin, Turin, Italy; Department of Psychology, University of Turin, Turin, Italy.
F CaudaGCS fMRI, Koelliker Hospital and University of Turin, Turin, Italy; Department of Psychology, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medication-overuse headache (MOH) is a secondary form of headache related to the overuse of triptans, analgesics and other acute headache medications. It is believed that MOH and substance addiction share some similar pathophysiological mechanisms. In this study we examined the whole brain resting state functional connectivity of the dorsal and ventral striatum in 30 patients (15 MOH and 15 non-MOH patients) to investigate if classification algorithms can successfully discriminate between MOH and non-MOH patients on the basis of the spatial pattern of resting state functional connectivity of the dorsal and ventral striatal region of interest. Our results indicated that both nucleus accumbens and dorsal rostral putamen functional connectivity could discriminate between MOH and non-MOH patients, thereby providing possible support to two interpretations. First, that MOH patients show altered reward functionality in line with drug abusers (alterations in functional connectivity of the nucleus accumbens). Second, that MOH patients show inability to break habitual behavior (alterations in functional connectivity of the dorsal striatum). In conclusion, our data showed that MOH patients were characterized by an altered functional connectivity of motivational circuits at rest. These differences could permit the blind discrimination between the two conditions using classification algorithms. Considered overall, our findings might contribute to the development of novel diagnostic measures.

Indexed as

Brain MappingAdultFemaleHeadache Disorders, SecondaryHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNucleus AccumbensPsychiatric Status Rating ScalesPsychological TestsRestYoung Adult

Identifiers

PMID27330969
PMCPMC4900511

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.