Evidence map›Paper›PMID 27330858›Full record

ArticlePeerJ2016

The oral microbiome of patients with axial spondyloarthritis compared to healthy individuals.

Jordan E Bisanz, Praema Suppiah, W Murray Thomson, Trudy Milne, Nigel Yeoh, Anita Nolan, Grace Ettinger, Gregor Reid, Gregory B Gloor, Jeremy P Burton and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  14. [Advances in research on axial spondyloarthritis].Zeitschrift fur Rheumatologie · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jordan E BisanzDepartment of Microbiology and Immunology, Western University, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada.
Praema SuppiahSchool of Dentistry, University of Otago , Dunedin , New Zealand.
W Murray ThomsonSchool of Dentistry, University of Otago , Dunedin , New Zealand.
Trudy MilneSchool of Dentistry, University of Otago, Dunedin, New Zealand; Sir John Walsh Research Institute, University of Otago, Dunedin, Otago, New Zealand.
Nigel YeohDunedin School of Medicine, University of Otago , Dunedin , New Zealand.
Anita NolanDunedin School of Medicine, University of Otago, Dunedin, New Zealand; Oral Health, AUT, Auckland, New Zealand.
Grace EttingerDepartment of Microbiology and Immunology, Western University, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada.
Gregor ReidDepartment of Microbiology and Immunology, Western University, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada; Division of Urology, Department of Surgery, University of Western Ontario, London, Ontario, Canada.
Gregory B GloorCanadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada; Department of Biochemistry, University of Western Ontario, London, Ontario, Canada.
Jeremy P BurtonDepartment of Microbiology and Immunology, Western University, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada; Division of Urology, Department of Surgery, University of Western Ontario, London, Ontario, Canada.
Mary P CullinanSchool of Dentistry, University of Otago, Dunedin, New Zealand; Sir John Walsh Research Institute, University of Otago, Dunedin, Otago, New Zealand.
Simon M StebbingsDunedin School of Medicine, University of Otago , Dunedin , New Zealand.
University of Otago · NZWestern University · CAAuckland University of Technology · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. A loss of mucosal tolerance to the resident microbiome has been postulated in the aetiopathogenesis of spondyloarthritis, thus the purpose of these studies was to investigate microbial communities that colonise the oral cavity of patients with axial spondyloarthritis (AxSpA) and to compare these with microbial profiles of a matched healthy population. Methods. Thirty-nine participants, 17 patients with AxSpA and 22 age and gender-matched disease-free controls were recruited to the study. For patients with AxSpA, disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants underwent a detailed dental examination to assess oral health, including the presence of periodontal disease assessed using probing pocket depth (PPD). Plaque samples were obtained and their bacterial populations were profiled using Ion Torrent sequencing of the V6 region of the 16S rRNA gene. Results.Patients with AxSpA had active disease (BASDAI 4.1 ± 2.1 [mean ± SD]), and a significantly greater prevalence of periodontitis (PPD ≥ 4 mm at ≥4 sites) than controls. Bacterial communities did not differ between the two groups with multiple metrics of α and β diversity considered. Analysis of operational taxonomic units (OTUs) and higher levels of taxonomic assignment did not provide strong evidence of any single taxa associated with AxSpA in the subgingival plaque. Discussion. Although 16S rRNA gene sequencing did not identify specific bacterial profiles associated with AxSpA, there remains the potential for the microbiota to exert functional and metabolic influences in the oral cavity which could be involved in the pathogenesis of AxSpA.

Indexed as

Axial spondyloarthritisMicrobiomeOral cavityPeriodontal disease

Identifiers

PMID27330858
PMCPMC4906644
OpenAlexW2408776675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.