ArticleJournal of diabetes investigation2016
Elasticity of the tibial nerve assessed by sonoelastography was reduced before the development of neuropathy and further deterioration associated with the severity of neuropathy in patients with type 2 diabetes.
Article in Journal of diabetes investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients: A Systematic Review and Meta-Analysis of Ultrasonography Studies.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Supersonic shear wave imaging of the tibial nerve for diagnosis of diabetic peripheral neuropathy: A meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Dynamic Changes in Peripheral Nerve Stiffness After Regional Anesthesia: Implications of Shear Wave Elastography in Adductor Canal Block.Journal of clinical medicine · 2026Review
- Ultrasound assessment of tibial nerve cross-sectional area in diabetic peripheral neuropathy in the Thai Population.PloS one · 2026Article
- Evaluation of Tibial and Median Nerves in Patients with Diabetic Peripheral Neuropathy Using Shear Wave Elastography.The Indian journal of radiology & imaging · 2025Article
- The evaluation of tibial nerve using shear-wave elastography and ultrasound in patients with systemic sclerosis: A cross-sectional study.Archives of rheumatology · 2023Article
- Advances in diagnosis and management of distal sensory polyneuropathies.Journal of neurology, neurosurgery, and psychiatry · 2023Review
- Normative Reference Values of the Tibial Nerve in Healthy Individuals Using Ultrasonography: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Article
- The normal value and influencing factors of shear wave elastography in healthy tibial nerves: A cross-sectional study.Health science reports · 2023Article
- Quantitative Ultrasound Techniques Used for Peripheral Nerve Assessment.Diagnostics (Basel, Switzerland) · 2023Review
- Sensitivity and specificity of high frequency ultrasound score (DCEC) in diabetic peripheral neuropathy.Journal of diabetes and metabolic disorders · 2022Article
- Role of shear wave elastography in treatment follow-up of leprosy neuropathy.Journal of ultrasound · 2022Article
- Interfascicular Gliding Dysfunction Relation with Focal Neuropathy in Diabetic Patients with Carpal Tunnel Syndrome.Journal of hand and microsurgery · 2022Review
- Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats.Journal of diabetes and metabolic disorders · 2021Article
- Article
- Gold Standard for Diagnosis of DPN.Frontiers in endocrinology · 2021Review
- Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- Shear wave elastography of the saphenous nerve.Medicine · 2020Observational
- Lumos for the long trail: Strategies for clinical diagnosis and severity staging for diabetic polyneuropathy and future directions.Journal of diabetes investigation · 2020Review
- Ulnar nerve instability in the cubital tunnel of asymptomatic volunteers.Journal of ultrasound · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionTo measure the elasticity of the tibial nerve using sonoelastography, and to associate it with diabetic neuropathy severity, the cross-sectional area of the tibial nerve and neurophysiological findings in type 2 diabetic patients. MATERIALS AND
methodsThe elasticity of the tibial nerve was measured as the tibial nerve:acoustic coupler strain ratio using high-resolution ultrasonography in 198 type 2 diabetic patients stratified into subgroups by neuropathy severity, and 29 control participants whose age and sex did not differ from the diabetic subgroups.
resultsThe elasticity of the tibial nerve in patients without neuropathy (P < 0.001) was reduced compared with controls (0.76 ± 0.023), further decreasing (0.655 ± 0.014 to 0.414 ± 0.018) after developing neuropathy. The cut-off value of elasticity of the tibial nerve that suggested the presence of neuropathy was 0.558. The area under the curve (0.829) was greater than that for the cross-sectional area (0.612). The cross-sectional area of the tibial nerve in diabetic patients without neuropathy (6.11 ± 0.13 mm(2)) was larger than that in controls (4.84 ± 0.16 mm(2)), and increased relative to neuropathy severity (P < 0.0001). The elasticity of the tibial nerve was negatively associated with neuropathy severity (P < 0.0001), cross-sectional area (P = 0.002) and 2000 Hz current perception threshold (P = 0.011), and positively associated with nerve conduction velocities (P < 0.0001).
conclusionsDetermining the elasticity of the tibial nerve in type 2 diabetic patients could reveal early biomechanical changes that were likely caused by thickened fibrous sheaths of peripheral nerves, and might be a novel tool for characterizing diabetic neuropathy.
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